PMID: 8613494Nov 1, 1995Paper

Inflammatory neuropathies--pathogenesis and the role of intravenous immune globulin

Journal of Clinical Immunology
F G van der MechéB C Jacobs

Abstract

The inflammatory neuropathies may be subdivided into an acute form, Guillain-Barré syndrome, and a chronic form referred to as chronic inflammatory demyelinating polyneuropathy. More recently a chronic, asymmetrical pure motor neuropathy with multifocal conduction blocks has been described. All three neuropathies are considered to be immune-mediated. Their response to therapy is discussed, with special emphasis on high-dose intravenous immune globulin. For Guillain-Barré syndrome the efficacy of intravenous immune globulin has been proven in a randomized clinical trial. In chronic inflammatory demyelinating polyneuropathy a response rate of over 60% in newly diagnosed patients is suggested. Clinical prognostic criteria, however, seem to be very important to predict the effect of intravenous immune globulin. In multifocal motor neuropathy intravenous immune globulin is at present the only alternative to cyclophosphamide.

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Citations

Apr 19, 2002·Journal of Neuroimmunology·Nathalie Escande-BeillardJosé Boucraut
Apr 2, 2003·Journal of Neuroimmunology·Mathias W R PletzAndreas J Steck
Jan 10, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ulrike H M ZiegnerHans D Ochs
Jul 14, 2005·Scandinavian Journal of Infectious Diseases·Lise HøjbergCourt Pedersen

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