Abstract
In inflammatory arthritis such as RA, osteoclastic activity is severely enhanced. GM-CSF was reportedly elevated in synovial fluid, but is a strong inhibitor of osteoclastogenesis; here lies a contradiction. Our objective was to examine what type of osteoclasts generate and resorb bone with resistance to GM-CSF in an inflammatory joint. Monocyte-derived cells generated in GM-CSF were morphologically and immunophenotypically different from both the conventional DC and macrophage. They could differentiate into osteoclasts in the presence of RANKL + M-CSF, acquiring a stronger osteoclastic activity under TNF treatment. Furthermore, their differentiation was not inhibited by GM-CSF, while monocyte-derived osteoclast differentiation was completely inhibited. The resorption was suppressed by GM-CSF, and the existence of another osteoclastic pathway has been suggested. Our findings indicate another type of osteoclast exists in inflammatory arthritis.
References
Feb 1, 1994·British Journal of Haematology·J CebonG Morstyn
Jan 1, 1993·The Journal of Clinical Investigation·S TanakaT Suda
Mar 17, 1997·The Journal of Experimental Medicine·N UdagawaM T Gillespie
May 4, 1999·The Journal of Clinical Investigation·S KotakeT Suda
Sep 24, 1999·Bone·L C HofbauerS Khosla
Nov 24, 1999·The Journal of Clinical Investigation·J A GracieI B McInnes
Sep 1, 2000·Science·S L Teitelbaum
Feb 24, 2001·Arthritis and Rheumatism·Y H Yang, J A Hamilton
Oct 6, 2001·Blood·T MiyamotoT Suda
Jul 23, 2002·Trends in Immunology·John A Hamilton
Mar 18, 2003·Endocrinology·J CornishI R Reid
May 16, 2003·Nature·Gary S Firestein
Apr 16, 2004·Nature·Takako KogaToshiyuki Takai
Aug 17, 2004·Blood·Aymeric RivollierChristine Servet-Delprat
Sep 11, 2004·Biochemical and Biophysical Research Communications·Jason M HodgeGeoffrey C Nicholson
Jan 26, 2005·The Journal of Clinical Investigation·Shi WeiSteven L Teitelbaum
Dec 5, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Jean E MulderMeryl S LeBoff
Dec 13, 2006·Nature Medicine·Bae Keun ParkCun-Yu Wang
Mar 24, 2007·Nature Reviews. Immunology·Hiroshi Takayanagi
May 26, 2007·Nature Reviews. Immunology·Iain B McInnes, Georg Schett
Citations
Sep 25, 2010·The Journal of Biological Chemistry·Alan W LauMargaret M Chou
Jan 11, 2012·Molecular Oral Microbiology·J E UmedaM P A Mayer
May 27, 2010·Cancer Research·Jinlu DaiEvan T Keller
Aug 25, 2010·Best Practice & Research. Clinical Rheumatology·Axel J HueberAshley M Miller
Nov 26, 2014·Nature Reviews. Rheumatology·Iannis E Adamopoulos, Elizabeth D Mellins
Dec 15, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Kazuhiro Yokota
Sep 28, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L LiX Yu
Jul 5, 2016·Inflammation and Regeneration·Aoi ShiomiTsuneyo Mimori
Mar 10, 2015·Expert Review of Clinical Immunology·John A Hamilton
Oct 14, 2009·International Journal of Immunopathology and Pharmacology·K YasuiT Morishima
Jul 1, 2021·Immunological Medicine·Tomoya AgemuraMasaru Ishii