Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Lucia HipólitoJose A Morón

Abstract

Pain management in opioid abusers engenders ethical and practical difficulties for clinicians, often resulting in pain mismanagement. Although chronic opioid administration may alter pain states, the presence of pain itself may alter the propensity to self-administer opioids, and previous history of drug abuse comorbid with chronic pain promotes higher rates of opioid misuse. Here, we tested the hypothesis that inflammatory pain leads to increased heroin self-administration resulting from altered mu opioid receptor (MOR) regulation of mesolimbic dopamine (DA) transmission. To this end, the complete Freund's adjuvant (CFA) model of inflammation was used to assess the neurochemical and functional changes induced by inflammatory pain on MOR-mediated mesolimbic DA transmission and on rat intravenous heroin self-administration under fixed ratio (FR) and progressive ratio (PR) schedules of reinforcement. In the presence of inflammatory pain, heroin intake under an FR schedule was increased for high, but attenuated for low, heroin doses with concomitant alterations in mesolimbic MOR function suggested by DA microdialysis. Consistent with the reduction in low dose FR heroin self-administration, inflammatory pain reduced motivation for ...Continue Reading

Citations

Jun 2, 2016·Neuroscience and Biobehavioral Reviews·D BorsookI Elman
Jan 12, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sevasti GaspariVenetia Zachariou
Dec 26, 2016·Peptides·Richard J Bodnar
Apr 30, 2017·Current Opinion in Behavioral Sciences·Catherine M Cahill, Anna Mw Taylor
Dec 3, 2016·The Journal of Pain : Official Journal of the American Pain Society·C Richard Chapman, Charles J Vierck
Jun 12, 2017·British Journal of Pharmacology·Adrianne R Wilson-Poe, Jose A Morón
Dec 7, 2017·Frontiers in Pharmacology·Marcos F DosSantosAlexandre F DaSilva
Jun 1, 2018·Annual Review of Neuroscience·Gregory CorderGrégory Scherrer
May 10, 2018·Frontiers in Psychiatry·Amie L SeverinoWendy M Walwyn
Aug 17, 2018·Pain·Jane C Ballantyne
Nov 14, 2019·Journal of Neuroscience Research·Patrick GrenierMary C Olmstead
Sep 23, 2020·Molecular Pharmacology·Kyle E ParkerReam Al-Hasani
Sep 21, 2017·Frontiers in Neuroanatomy·Dave J HayesMojgan Hodaie
Aug 22, 2018·Journal of Experimental Neuroscience·Diana I Lurie
Jun 1, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Xinhe LiuFei Luo
Aug 10, 2020·Journal of Neuroscience Research·Jesús David LorenteLucía Hipólito
Oct 9, 2019·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Antoine BecharaJeffrey S Stein
Jan 17, 2021·Experimental Neurology·Tannia GutierrezAndrea G Hohmann
Feb 2, 2021·Neuropharmacology·Arbi NazarianThomas J Martin
Dec 12, 2018·Neuroscience and Biobehavioral Reviews·Sandra D Comer, Catherine M Cahill
Mar 12, 2021·Pain Reports·Adrianne R Wilson-PoeJose A Morón
Nov 1, 2020·Trends in Biochemical Sciences·Javier CuitaviMeritxell Canals
Jul 14, 2021·Pain·Ann M GregusMatthew W Buczynski
Aug 25, 2021·Psychopharmacology·Nidia Espinoza SerranoArbi Nazarian

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