Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage

Cellular and Molecular Neurobiology
Lei YeHongwei Cheng

Abstract

Cerebral hemorrhage is a series of devastating cerebrovascular diseases with high mortality, morbidity and recurrence rate. Localized and systemic immuno-reactions are involved. Aggregation of immunocytes, which were both recruited from the peripheral circulation and resident in the central nervous system, is induced and activated by hematoma-related blood components. Subsequently, various cytokines, chemokines, free radicals and toxic chemicals are secreted to participant host defense responses. Among these, neuro-inflammation plays critical roles in both the pathologic processes of secondary injuries and recovery of neural damages. Numerous treatment strategies have been proposed, aiming at controlling the balance between anti- and proinflammation. Here, we summarized our current understanding and potential clinical applications for cytokines of the interleukin family in the pathogenesis of hemorrhagic stroke. In addition, we conducted protein-protein network, gene ontology and KEGG analysis on the interleukins using online bioinformatic tools to further elaborate the comprehensive mechanisms of interleukins in cerebral hemorrhage.

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Citations

Feb 21, 2019·Journal of Experimental Neuroscience·Adejoke Yetunde OnaolapoThomas I Nathaniel
Sep 27, 2019·Annals of Clinical and Translational Neurology·Jeong-Min KimKon Chu
Feb 17, 2021·Journal of Medical Virology·Zhiquan HeXueyong Huang
Aug 8, 2021·International Journal of Molecular Sciences·Anthony FringuelloMichael W Graner

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