Inflammatory pseudotumor in head and neck

Auris, Nasus, Larynx
Yuichi SegawaShizuo Komune

Abstract

Inflammatory pseudotumor (IPT) is a tumefactive lesion characterized by fibroblastic proliferations and a prominent inflammatory component. It behaves as a locally benign or aggressive lesion, clinically and radiologically mimicking a neoplastic process. Numerous entities can be diagnosed as IPT, from reactive lesions to true neoplasms. The diagnosis of IPT requires further elaboration, and IPT should be distinguished from other similar entities such as inflammatory myofibroblastic tumor and IgG4-related sclerosing disease. We report two cases of IPT arising from the head and neck region. One occurred at the orbit and the other at the parapharyngeal space. Histologically, they showed aggregates of myofibroblasts and inflammatory cells. Immunohistochemically, the number of IgG4-positive cells was less than 40% of the number of IgG positive cells, and the myofibroblastic cells were negative for anaplastic lymphoma kinase. The diagnosis was IPT/not otherwise specified. One patient was treated by systemic administration of corticosteroid and had good response. The other, who was treated by local administration of corticosteroid, partially responded and is currently stable with limited disease. IPT has been reported to occur in vari...Continue Reading

References

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Citations

Mar 17, 2016·Annals of Maxillofacial Surgery·Jagdeep S ThakurN K Mohindroo
Dec 30, 2014·Head & Neck·Brian RodgersJames Lin
Sep 10, 2016·American Journal of Otolaryngology·Cameron C WickCliff A Megerian
Jun 2, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Timothy E OrtlipRonna Hertzano
Apr 13, 2018·BMJ Case Reports·Anna W LaVigneDanielle N Margalit
Apr 15, 2020·Ear, Nose, & Throat Journal·Javier Gómez-HervásEsteban Merino Gálvez
Oct 13, 2017·The Journal of Craniofacial Surgery·William Phillip Pereira da SilvaLaurindo Moacir Sassi
Dec 30, 2017·Pediatric Blood & Cancer·Till-Martin TheilenThomas Lehrnbecher
Jun 22, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Blaine D Smith, Calhoun D Cunningham

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