Inflammatory response after phacoemulsification treated with 0.5% prednisolone acetate or vehicle.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Katrin LorenzGerd U Auffahrt

Abstract

To compare the inflammatory response after phacoemulsification and intraocular lens implantation, using postoperative treatment with 0.5% prednisolone acetate eye drops or vehicle. A multi-center randomized double-masked vehicle-controlled, parallel group phase IV study. Sixty-two eyes of 62 patients undergoing phacoemulsification were examined at five German university eye hospitals (Mainz, Heidelberg, Bonn, Erlangen, Frankfurt/Main). Patients received either 0.5% prednisolone acetate eye drops (group 1) or vehicle eye drop solution (group 2) four times a day until day 2, then open-label treatment with 0.5% prednisolone acetate eye drops four times a day continued until day 14 for all patients. Postoperative inflammation was evaluated by using laser flare photometry. Secondary efficacy variables included visual acuity, intraocular pressure, corneal edema, bulbar conjunctival hyperemia and ocular discomfort. In group 1, median flare rose from 7.4 photon counts/ms preoperatively to 31.0 photon counts/ms at day 1. In group 2, the flare increased from 8.6 photon counts/ms preoperatively to 30.5 photon counts/ms at day 1. The differences between the groups were not statistically significant. At day 3, flare measures were reduced in...Continue Reading

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Citations

Nov 3, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Veronica PianiniFranco Passani
Mar 30, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Marilita M MoschosTheodoros N Sergentanis
Aug 9, 2011·The Journal of International Medical Research·N KnezD Pahor
Aug 9, 2020·Clinical Ophthalmology·Kerry D SolomonRichard Potvin
Feb 12, 2021·Drug Delivery and Translational Research·Chee Wai WongTina T Wong
Dec 10, 2009·Current Opinion in Ophthalmology

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