Abstract
To compare the inflammatory response after phacoemulsification and intraocular lens implantation, using postoperative treatment with 0.5% prednisolone acetate eye drops or vehicle. A multi-center randomized double-masked vehicle-controlled, parallel group phase IV study. Sixty-two eyes of 62 patients undergoing phacoemulsification were examined at five German university eye hospitals (Mainz, Heidelberg, Bonn, Erlangen, Frankfurt/Main). Patients received either 0.5% prednisolone acetate eye drops (group 1) or vehicle eye drop solution (group 2) four times a day until day 2, then open-label treatment with 0.5% prednisolone acetate eye drops four times a day continued until day 14 for all patients. Postoperative inflammation was evaluated by using laser flare photometry. Secondary efficacy variables included visual acuity, intraocular pressure, corneal edema, bulbar conjunctival hyperemia and ocular discomfort. In group 1, median flare rose from 7.4 photon counts/ms preoperatively to 31.0 photon counts/ms at day 1. In group 2, the flare increased from 8.6 photon counts/ms preoperatively to 30.5 photon counts/ms at day 1. The differences between the groups were not statistically significant. At day 3, flare measures were reduced in...Continue Reading
References
Jul 1, 1992·Journal of Cataract and Refractive Surgery·T OshikaN Miyata
Apr 1, 1992·Klinische Monatsblätter für Augenheilkunde·M WenzelM Reim
Jun 1, 1991·The British Journal of Ophthalmology·S M ShahS E Smith
Jul 1, 1990·Acta Anaesthesiologica Scandinavica·M EngbergG E Cold
Feb 1, 1984·American Journal of Ophthalmology·M SawaH Shimizu
Apr 1, 1984·Ophthalmology·T J LiesegangR F Brubaker
Apr 1, 1995·Ophthalmology·Y Guex-CrosierC P Herbort
Jun 1, 1995·Archives of Ophthalmology·C W Roberts, K M Brennan
Sep 1, 1994·Journal of Cataract and Refractive Surgery·C L LinJ H Liu
Feb 1, 1994·Archives of Ophthalmology·N R PoweE P Steinberg
Apr 1, 1996·Ophthalmology·C W Roberts
Aug 1, 1996·Archives of Ophthalmology·M Raizman
Mar 1, 1996·Klinische Monatsblätter für Augenheilkunde·V HessemerA Jacobi
Jan 1, 1996·Journal of Cataract and Refractive Surgery·M V PandeJ Marshall
Aug 1, 1997·Acta Ophthalmologica Scandinavica·C G LaurellB Lundgren
Mar 21, 1998·Ophthalmology·L RossettiK Dickersin
Nov 24, 1998·Acta Ophthalmologica Scandinavica·C G LaurellS Syrén-Nordqvist
Nov 24, 1998·Acta Ophthalmologica Scandinavica·C G Laurell
Feb 26, 2000·Ophthalmology·H B DickN Pfeiffer
May 5, 2001·American Journal of Ophthalmology·M F EstafanousR Chauhan
Nov 13, 2001·Eye·P S Suresh, N P Jones
Nov 26, 2002·The British Journal of Ophthalmology·C-G Laurell, C Zetterström
Citations
Nov 3, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Veronica PianiniFranco Passani
Mar 30, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Marilita M MoschosTheodoros N Sergentanis
Aug 20, 2014·Ophthalmology and Therapy·Uwe PleyerPaolo Rama
Sep 14, 2012·Acta Ophthalmologica·Michel WeberCatherine M Allaire
Mar 7, 2014·Toxicology·Noriaki NagaiYoshikazu Shimomura
Aug 9, 2011·The Journal of International Medical Research·N KnezD Pahor
Jul 2, 2016·Eye·M E WilsonS R Lambert
Aug 9, 2020·Clinical Ophthalmology·Kerry D SolomonRichard Potvin
Nov 1, 2020·The British Journal of Ophthalmology·Chee Wai WongTina T Wong
Feb 12, 2021·Drug Delivery and Translational Research·Chee Wai WongTina T Wong
Dec 10, 2009·Current Opinion in Ophthalmology