Inflammatory response during bacterial meningitis is unchanged in Fas- and Fas ligand-deficient mice

Journal of Neuroimmunology
R PaulU Koedel

Abstract

Fas (CD95) and Fas ligand (FasL, CD95L) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival. Increased levels of soluble Fas and FasL are found in cerebrospinal fluid (CSF) samples of patients with bacterial meningitis but not in controls. Functional FasL (gld)- or Fas (lpr)-deficient mice were used to assess their role in the pathophysiology of pneumococcal meningitis. Induction of meningitis in wild-type (WT) mice caused an increase in CSF white blood cell (WBC) count, intracranial pressure (ICP), and vessel permeability, paralleled by a worse clinical status at 24 h. The inflammatory response was accompanied by elevated levels of IL-1beta, MMP-2, and MMP-9 in the brain. Neither gld- nor lpr-mice showed significant differences in the above-mentioned pneumococci-induced pathophysiological alterations. These results indicate that Fas and FasL are not essential in the regulation of the acute inflammatory response during pneumococcal meningitis.

Citations

Jun 9, 2009·Interdisciplinary Perspectives on Infectious Diseases·U R GoonetillekeS B Gordon
Jan 26, 2016·Trends in Microbiology·Federico IovinoJan Maarten van Dijl
Feb 22, 2008·Brain Research·Aditi SharangpaniMichael J Bell
Dec 18, 2013·Journal of Neuropathology and Experimental Neurology·Simone C TauberArno Reich
Aug 26, 2006·Nature Clinical Practice. Neurology·Diederik van de BeekEelco F M Wijdicks
Apr 8, 2006·Current Opinion in Pediatrics·Denis Grandgirard, Stephen L Leib
Oct 7, 2005·Expert Review of Anti-infective Therapy·E David G McIntosh

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