Inflammatory response in Alzheimer's disease

The Tohoku Journal of Experimental Medicine
H Akiyama

Abstract

Microglia belong to the mononuclear phagocyte system. They represent the brain resident tissue macrophages and function as the scavenger cells in brain. In Alzheimer's disease (AD), microglia become activated. Reactive microglia aggregate around senile plaque beta-amyloid and neurofibrillary tangles. Heavy accumulation of these pathological debris in postmortem, however, indicates the failure or, at best, partial success of the removal. It is supposed that continued activation of microglia in these lesions elicits a persistent inflammatory response. In fact, activation fragments of the complement system have been detected in association with beta-amyloid deposits and extracellular ghost tangles. Thrombin, a central serine protease of the coagulation pathway, is also deposited in these pathological debris. Both complements and thrombin could augment the biochemical, synthetic and phagocytic capacities of microglia. Microglia, in turn, might play a major role for the activation of complement and coagulation systems in brain. The available evidence strongly suggests a significant similarity between the chronic inflammation and the tissue response in AD lesions, supporting a notion that the inflammatory process is a part of Alzheim...Continue Reading

Citations

Nov 20, 1998·Journal of Neuroscience Research·V R LombardiR Cacabelos
Feb 28, 2009·In Vitro Cellular & Developmental Biology. Animal·Christine E Gilling, Kimberly A Carlson
Jan 27, 2004·Journal of Neuroimmunology·Carol A ColtonMichael P Vitek
Nov 6, 2002·Journal of Neuroimmunology·Akira TeraoYvonne R Freund
Jan 1, 2003·Journal of Neuroimmunology·M Czapiga, C A Colton
Jan 1, 2009·Journal of Ophthalmology·Paul P ConnellStephen Beatty
Sep 29, 2006·Journal of Neuroinflammation·Carol A ColtonMichael P Vitek
Dec 6, 2012·Translational Neurodegeneration·Xiao-Guang Luo, Sheng-Di Chen
Aug 8, 2013·The International Journal of Neuroscience·M Obulesu, M Jhansilakshmi
Jun 27, 2012·Progress in Neurobiology·Karlijn J DoornAnne-Marie van Dam
Aug 17, 2011·Brain, Behavior, and Immunity·Brianne Magouirk BettcherJoel H Kramer
Mar 23, 2010·Cell·Christopher K GlassFred H Gage
Nov 27, 2014·Frontiers in Aging Neuroscience·Heather M WilkinsRussell H Swerdlow
Nov 1, 2015·Brain, Behavior, and Immunity·Wolfgang J Streit, Qing-Shan Xue
Jul 10, 2016·Journal of Alzheimer's Disease : JAD·Reginald C Adiele, Chiedukam A Adiele
Apr 14, 1999·Psychiatry and Clinical Neurosciences·K KosakaH Arai
Jan 15, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daniel FelskyUNKNOWN authors of the Alzheimer’s Disease Neuroimaging Initiative
Nov 18, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Christel ClaesCatherine M Verfaillie
Jun 9, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Justin MironUNKNOWN PREVENT-AD research group
Jun 23, 2000·Annals of the New York Academy of Sciences·C A ColtonM P Vitek
Mar 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lindsay A WelikovitchA Claudio Cuello
Mar 7, 2020·International Journal of Molecular Sciences·Pedram HonarpishehBhanu P Ganesh
May 7, 2020·International Journal of Molecular Sciences·Isabel M GuijarroMarta Monzón
Jun 25, 2003·The Journal of Biological Chemistry·Zhiming SuoBarry W Festoff
Nov 20, 2020·Neuroscience·Ana-Maria DobriMihail Eugen Hinescu
Jul 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Seung Yun Lee, Sun Jin Hur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.