Inflammatory Response of Ischemic Tolerance in Circulating Plasma: Preconditioning-Induced by Transient Ischemic Attack (TIA) Phenomena in Acute Ischemia Patients (AIS)

Frontiers in Neurology
Laura Colàs-CampàsFrancisco Purroy

Abstract

Introduction: Ischemic tolerance (IT) refers to a state where cells are resistant to the damaging effects caused by periods of ischemia. In a clinical scenario, the IT phenomenon would be activated by a recent transient ischemic attack (TIA) before an ischemic stroke (IS). The characterization of inflammatory protein expression patterns will contribute to improved understanding of IT. Methods: A total of 477 IS patients from nine hospitals, recruited between January 2011 and January 2016, were included in the current study and divided in three groups: 438 (91.9%) patients without previous TIA (group 1), 22 (4.6%) patients who suffered TIA 24 h before IS (group 2), and 17 (3.5%) patients who suffered TIA between 24 h and 7 days prior to IS (group 3). An inflammatory biomarker panel (IL-6, NT-proBNP, hsCRP, hs-Troponin, NSE, and S-100b) on plasma and a cytokine antibody array was performed to achieve the preconditioning signature potentially induced by TIA phenomena. Primary outcome was modified rankin scale (mRs) score at 90 days. Results: Recent previous TIA was associated with better clinical outcome at 90 days (median mRS of group 1: 2.0 [1.0-4.0]; group 2: 2.0 [0.0-3.0]; group 3: 1.0 [0-2.5]; p = 0.086) and smaller brain les...Continue Reading

References

Oct 11, 1991·Brain Research·K KitagawaT Kamada
Sep 2, 1999·Stroke; a Journal of Cerebral Circulation·M WeihK M Einhäupl
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takaaki Kirino
May 15, 2003·Trends in Neurosciences·Ulrich DirnaglJohn M Hallenbeck
Dec 19, 2003·Annals of Neurology·José CastilloAntonio Dávalos
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·Susanne WegenerUNKNOWN MRI in Acute Stroke Study Group of the German Competence Network Stroke
Nov 10, 2004·Journal of Digital Imaging·Antoine RossetOsman Ratib
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Francisco PurroyJosé Alvarez-Sabín
Oct 2, 2008·Neurological Research·Gokhan Yilmaz, D Neil Granger
Nov 19, 2009·Journal of Translational Medicine·Shaheen E LakhanMagdalena Hofer
Feb 5, 2010·Journal of Leukocyte Biology·Rong JinGuohong Li
Oct 20, 2010·Annals of the New York Academy of Sciences·Anna MoranchoJoan Montaner
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
Mar 2, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Corine Aboa-EbouléClaire Bonithon-Kopp
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Oct 19, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Takao HoshinoShinichiro Uchiyama
Oct 28, 2011·Nature Neuroscience·Costantino Iadecola, Josef Anrather
Aug 29, 2012·Molecular and Cellular Neurosciences·H B Stolp
Dec 1, 2012·Current Opinion in Neurology·Srinivasan V NarayananMiguel A Perez-Pinzon
Jan 25, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Francisco PurroyUNKNOWN Stroke Project of the Spanish Cerebrovascular Diseases Study Group
Jun 27, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F PurroyI Benabdelhak
Oct 24, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Alejandro BustamanteJoan Montaner
Nov 21, 2014·Progress in Brain Research·Jennifer VandoorenGhislain Opdenakker
Dec 2, 2014·Journal of the Neurological Sciences·Hua YeLei Guo
Mar 15, 2015·Stroke; a Journal of Cerebral Circulation·Víctor LlombartJoan Montaner
Nov 21, 2015·Nature Reviews. Neurology·David C HessXunming Ji
Oct 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ashley McDonough, Jonathan R Weinstein

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Methods Mentioned

BETA
protein array
antibody array
array technology
antibody array technology

Software Mentioned

Polygon
GenePix Pro
SPSS
OsiriX
PANTHER
GO

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