PMID: 9165360Mar 1, 1997Paper

Inflammatory response to aorto-bifemoral graft surgery

International Angiology : a Journal of the International Union of Angiology
H N PärssonL Norgren

Abstract

To evaluate the systemic release of major cytokines and complemental activation during elective aorto-bifemoral bypass surgery and the influence on the postoperative course. Prospective randomised study. University hospital, Sweden. Fourteen consecutive patients with aorto-iliac occlusive disease were randomised to receive either a bifurcated e PTFE graft with stretch properties or a collagen coated Dacron graft. Immunologic parameters were assessed and included the cytokines TNF alpha (tumor necrosis factor), IL-6, IL-8, S-IL-2R and complemental factor C5a. Furthermore, acute plasma proteins, including C-reactive protein, and the different white blood cell fractions were determined. Sampling was performed frequently during surgery and postoperatively up to one month. An increase of serum-TNF alpha levels was observed early after declamping. This response preceded an increase of IL-6 levels and of C-reactive protein. No release of IL-8 was identified. A significant correlation between TNF alpha, IL-6 and C-reactive protein was observed (p < 0.001). A positive correlation was also observed for the degree of surgical trauma (blood loss). No significant differences between the two graft materials were encountered. The complemental...Continue Reading

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Related Papers

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
J TiekI Fourneau
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
Ph RemyH Massin
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
I FourneauA Nevelsteen
© 2021 Meta ULC. All rights reserved