Inflammatory serum markers up to 5 years after comprehensive periodontal therapy of aggressive and chronic periodontitis

Clinical Oral Investigations
Tatjana RamichPeter Eickholz

Abstract

The aim of the study is to assess the long-term effect of active periodontal therapy on serum inflammatory parameters in patients with aggressive (AgP) and chronic (ChP) periodontitis in a non-randomised clinical study. Twenty-five ChP and 17 AgP were examined clinically prior to (baseline), 12 weeks and 60 months after subgingival debridement of all pockets within 2 days. Systemic antibiotics were prescribed if Aggregatibacter actinomycetemcomitans was detected (10 AgP, 8 ChP), flap surgery was rendered if required. Neutrophil elastase (NE), C-reactive protein (CRP), lipopolysaccharide binding protein, interleukin 6, 8, and leukocyte counts were assessed at baseline, 12 weeks and 60 months. Clinical parameters improved significantly in both groups from 12 weeks to 60 months. Eleven AgP and 18 ChP patients received surgical treatment after the 12 weeks examination. Only 3 patients in each group attended ≥ 2 supportive maintenance visits per year. NE and CRP were significantly higher in AgP than ChP at baseline and 60 months (p < 0.01). For leukocyte counts in ChP, significant changes were observed (baseline: 6.11 ± 1.44 nl-1; 12 weeks: 5.34 ± 1.40 nl-1; 60 months: 7.73 ± 2.89 nl-1; p < 0.05). Multiple regression analysis identi...Continue Reading

References

Jan 1, 1972·Journal of Periodontology·T J O'LearyJ E Naylor
Jan 1, 1997·Journal of Clinical Periodontology·K S KornmanG W Duff
Mar 15, 2001·Journal of Periodontal Research·P P HujoelM A Listgarten
Jun 25, 2005·American Heart Journal·Gerald SeinostErnst Pilger
Nov 10, 2005·Journal of Periodontology·Bruno G Loos
Mar 3, 2007·The New England Journal of Medicine·Maurizio S TonettiJohn Deanfield
Apr 17, 2007·Journal of Clinical Periodontology·Beate SchacherPeter Eickholz
Jun 5, 2007·The Journal of the American Dental Association·UNKNOWN American Heart Association, UNKNOWN American Dental Association Division of Communications
Aug 11, 2007·Clinical Oral Investigations·Ti-Sun KimPeter Eickholz
Jan 18, 2008·Journal of Clinical Periodontology·Peter EickholzBernadette Pretzl
Feb 26, 2008·Journal of Clinical Periodontology·Spiros ParaskevasBruno G Loos
Jun 20, 2008·Journal of Clinical Periodontology·Willem NesseArjan Vissink
Dec 9, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Martin WohlfeilPeter Eickholz
Feb 26, 2011·Journal of Clinical Periodontology·Moritz Kebschull, Panos N Papapanou
Oct 20, 2011·Clinical Oral Investigations·Martin WohlfeilPeter Eickholz
Nov 5, 2011·Oral Diseases·L NibaliN Donos
Feb 26, 2013·Journal of Clinical Periodontology·Peter EickholzMartin Wohlfeil
Jun 12, 2013·Clinical Oral Investigations·Susanne ScharfPeter Eickholz
Nov 16, 2013·BMC Medicine·Adam K H Usher, Robert A Stockley
Feb 18, 2014·Journal of Clinical Periodontology·Christoph A RamseierGiovanni E Salvi
Aug 8, 2015·Journal of Clinical Periodontology·Inga HarksBenjamin Ehmke
Nov 1, 2005·Journal of Periodontology·Bruno G Loos

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Citations

Aug 31, 2019·Clinical Oral Investigations·Markus LakyAlice Assinger
Dec 2, 2020·Journal of Clinical Periodontology·Fernando Oliveira CostaLuís Otávio Miranda Cota
Oct 18, 2020·Experimental Hematology·João BotelhoFrancesco D'Aiuto
Nov 5, 2020·Cytokine·Nidhi MedaraNeil M O'Brien-Simpson
Apr 1, 2021·Medicine·Francina Maria Escobar ArregocésCatalina Latorre Uriza
Jul 3, 2021·International Journal of Molecular Sciences·Mahmoud ElashiryChristopher W Cutler
Aug 17, 2021·Frontiers in Immunology·Vanessa MachadoFrancesco D'Aiuto

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