Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication

Brain, Behavior, and Immunity
C Rummel

Abstract

Immune-to-brain communication pathways involve humoral mediators, including cytokines, central modulation by neuronal afferents and immune cell trafficking to the brain. During systemic inflammation these pathways contribute to mediating brain-controlled sickness symptoms including fever. Experimentally, activation of these signaling pathways can be mimicked and studied when injecting animals with pathogen associated molecular patterns (PAMPS). One central component of the brain inflammatory response, which leads, for example, to fever induction, is transcriptional activation of brain cells via cytokines and PAMPS. We and others have studied the spatiotemporal activation and the physiological significance of transcription factors for the induction of inflammation within the brain and the manifestation of fever. Evidence has revealed a role of nuclear factor (NF)κB in the initiation, signal transducer and activator of transcription (STAT)3 in the maintenance and NF-interleukin (IL)6 in the maintenance or even termination of brain-inflammation and fever. Moreover, psychological stressors, such as exposure to a novel environment, leads to increased body core temperature and genomic NF-IL6-activation, suggesting a potential use of ...Continue Reading

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Citations

Nov 11, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Joachim Roth, Michal Horowitz
Nov 16, 2018·Journal of Child Neurology·Amira Hamed DarwishNahla A Nosair
Apr 17, 2019·Experimental and Therapeutic Medicine·Wen-Fang ZhangJing-Jing Cui
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Jul 3, 2021·Pharmaceuticals·Verena PeekChristoph Rummel

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