Inflammatory/demyelinating central nervous system involvement in familial Mediterranean fever (FMF): coincidence or association?

Journal of Neurology
G Akman-DemirM Eraksoy

Abstract

Familial Mediterranean fever (FMF) is an inherited inflammatory disease characterized by recurrent febrile polyserositis. Central nervous system (CNS) involvement in FMF is uncommon, but recently cases with multiple sclerosis (MS) and FMF have been reported. Here we assess patients with both FMF and MS, in order to clarify any relationship between FMF and MS, and to evaluate disease characteristics. Our MS database between 1986-2005 was screened retrospectively, and patients with both FMF and inflammatory/demyelinating CNS disease were evaluated among a total of 2800 patients including definite MS (n = 2268) and other demyelinating disorders. There were 12 patients with FMF, who developed a CNS disorder with multifocal white matter lesions. Median age at onset of FMF was 7 years, and median age at neurological onset was 26.8 years. Nine patients (including two siblings) had definite MS according to clinical and MRI findings, whereas 3 patients had atypical features suggesting other demyelinating disorders. Disease severity varied among the patients between very mild to a fatal course. All 8 patients evaluated for oligoclonal IgG bands in CSF were positive. The rate of FMF among our patients with definite MS is almost 4 times th...Continue Reading

References

Sep 15, 1992·American Journal of Medical Genetics·M ShohatE Sohar
Nov 1, 1988·The American Journal of Medicine·A D Schwabe, J B Monroe
Jun 1, 1996·Brain : a Journal of Neurology·J W ThorpeD H Miller
Sep 1, 1997·Nature Genetics·UNKNOWN French FMF Consortium
Aug 1, 1997·Journal of Neurology·M A Topçuoğlu, R Karabudak
Oct 23, 1997·Arthritis and Rheumatism·A LivnehM Pras
Nov 20, 1997·The New England Journal of Medicine·B M Babior, Y Matzner
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R KarabudakI Saatci
Jul 1, 1961·Archives of Internal Medicine·M ELIAKIM, E BENTAL
Oct 25, 2003·Journal of Neuroimmunology·M EraksoyUNKNOWN Turkish Multiple Sclerosis Genetics Study Group
Oct 25, 2003·Journal of Neuroimmunology·M EraksoyUNKNOWN Turkish Multiple Sclerosis Genetics Study Group
Aug 10, 2004·Human Mutation·Isabelle TouitouCyril Sarrauste de Menthiere
Oct 8, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C YücesanN Türkçapar
Jan 12, 2005·Medicine·Mehmet TuncaUNKNOWN Turkish FMF Study Group

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Citations

Oct 16, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nilufer KaleOsman Tanik
Jan 9, 2013·Journal of Molecular Neuroscience : MN·Serbulent YigitOmer Ates
Feb 19, 2008·Current Opinion in Rheumatology·John G Ryan, Raphaela Goldbach-Mansky
Feb 9, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G YahalomA Livneh
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·O FeldA Livneh
Sep 24, 2008·Revue neurologique·A GuinetF Pico
Mar 13, 2015·Clinical Rheumatology·Donato RiganteLuca Cantarini
May 15, 2015·Thrombosis Journal·Micaela La ReginaRaffaele Manna
Sep 3, 2016·Rheumatology International·Ahmet KaraarslanAfig Berdelı
Feb 18, 2012·Multiple Sclerosis : Clinical and Laboratory Research·T KümpfelP Lohse
Jan 18, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Ine PauwelsAn Goris
Sep 30, 2010·Multiple Sclerosis : Clinical and Laboratory Research·A BlaschekT Kümpfel
Jun 14, 2017·The Journal of International Medical Research·Samet YılmazHatice Balaban
Oct 11, 2019·Rheumatology·Banu Balcı-PeynircioğluSeza Özen
Jun 22, 2020·Journal of Neuroinflammation·Elisabeth MulazzaniTania Kümpfel
Sep 15, 2018·Der Nervenarzt·C Trebst, T Kümpfel

❮ Previous
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