Inflatable Penile Prostheses Implantation: Does Antibiotic Exposure Matter?

Sexual Medicine
Ryan M ChanyiJeremy P Burton

Abstract

Inflatable penile prosthetic (IPP) infections are unusual but carry high patient morbidity and healthcare costs. To increase the bactericidal effect of IPP tubing material to prevent future bacterial infections and to determine whether this effect is time-dependent. A modified disk diffusion assay was developed to measure the zones of inhibition against Escherichia coli, Proteus mirabilis, Staphylococcus aureus, and Staphylococcus epidermidis when tubing was immersed in gentamycin, ampicillin, tetracycline, kanamycin, erythromycin, or ciprofloxacin. To further assess the efficacy of this approach, IPP tubing was exposed to ampicillin or ciprofloxacin for 30 seconds, 2 minutes, 10 minutes, or 60 minutes. Bacterial zones of inhibition against IPP tubing material exposed to various treatments. IPP tubing was more effective against Gram-positive bacteria (S aureus and S epidermidis) then Gram-negative bacteria (E coli and P mirabilis). Immersing IPP tubing material in ampicillin or ciprofloxacin increased bactericidal effect of tubing material against Gram-positive and Gram-negative bacteria, respectively. The observed inhibitory effect was time dependent. Exposing IPP to a specific antimicrobial directly before implantation increa...Continue Reading

Citations

Feb 1, 2019·Current Urology Reports·Soum D LokeshwarRanjith Ramasamy
Jul 8, 2020·Sexual Medicine Reviews·Benjamin M Dropkin, Melissa R Kaufman

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Methods Mentioned

BETA
Assay

Software Mentioned

GraphPad Prism

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