Infliximab and anterior optic neuropathy: case report and review of the literature.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Jane W Chan, Alberto Castellanos

Abstract

Anti-tumor necrosis factor alpha (TNF alpha) agents have been increasingly used to treat patients with Crohn's disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and persistent uveitis. We describe a 68-year-old man with Crohn's esophagitis who developed a possible bilateral toxic anterior optic neuropathy during infliximab infusion. This is an observational case report, with review of the PubMed literature from 1977 to present. This 68-year-old man with a 2-year history of Crohn's esophagitis developed acute bilateral visual loss during his third infliximab infusion. His clinical features and laboratory tests were characteristic for a bilateral anterior optic neuropathy. Only three cases of possible infliximab-associated anterior optic neuropathy have been reported in the literature to date. It is important to consider the possibility of anterior optic neuropathy, in addition to retrobulbar optic neuritis, in patients who experience sudden-onset visual loss while being treated with infliximab.

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Citations

Dec 19, 2013·Anais Brasileiros De Dermatologia·Luiz Gustavo Martins da SilvaMarilda Aparecida Milanez Morgado de Abreu
Dec 27, 2011·Rheumatology International·César FaillaceJozélio Freire de Carvalho
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Jan 14, 2016·Journal of Crohn's & Colitis·Benjamin AlexandreUNKNOWN ECCO CONFER investigators
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Mar 10, 2017·Clinical Neuropharmacology·Marta de Frutos-LezaunJavier Olascoaga
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Dec 6, 2019·Expert Opinion on Drug Safety·Maria Soledad OrmaecheaQuan Dong Nguyen
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May 11, 2017·Chemical Biology & Drug Design·Xinyao LiuYan Zhang

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