Infliximab in Takayasu arteritis: a safe alternative?

Clinical Rheumatology
Zaharenia Th KarageorgakiFotini N Skopouli

Abstract

To test the efficacy of Infliximab, a chimeric monoclonal antibody against TNF-alpha, in the treatment of Takayasu arteritis. We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients with Takayasu arteritis. Three out of four patients responded to infliximab treatment, while two of them retained the response during a two-year follow up. A higher dose regimen (5 mg/kg), however, was eventually warranted for two of the responders. No major side effects were noted. Infliximab might be an effective and safe alternative for patients with Takayasu arteritis.

References

Jul 1, 1985·Annals of Internal Medicine·J H ShelhamerA S Fauci
Apr 1, 1994·Arthritis and Rheumatism·G S HoffmanA S Fauci
Jun 1, 1994·Annals of Internal Medicine·G S KerrG S Hoffman
Feb 10, 1999·International Journal of Cardiology·S NoguchiJ N Wilcox
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
Apr 9, 2001·Hospital Medicine·P Emery
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·D M Parham
Aug 11, 2001·Lancet·P P SfikakisN N Markomichelakis
Jun 28, 2002·Cleveland Clinic Journal of Medicine·Michael C Sneller
Jul 9, 2002·Journal of Clinical Pathology·S L JohnstonM M Gompels
Jul 13, 2004·Arthritis and Rheumatism·Gary S HoffmanPatrick Liang
Oct 18, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·E P CherouvimM N Manoussakis

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Citations

Jan 10, 2012·Rheumatology·Arsène MekinianUNKNOWN Club Rhumatismes et Inflammation, French Vasculitis Study Group and Société Nationale Française de Médecine Interne
Dec 17, 2008·Current Opinion in Rheumatology·Sharon A Chung, Philip Seo
Jan 1, 2011·International Journal of Clinical Rheumatology·Charles F Henderson, Philip Seo
Oct 8, 2013·Rheumatology·Gokhan KeserKenan Aksu
Aug 31, 2010·QJM : Monthly Journal of the Association of Physicians·M P KarampetsouP P Sfikakis
Oct 24, 2009·Rheumatology International·Paola Sabrina BuonuomoAlberto G Ugazio
Jan 21, 2011·Rheumatology International·Nazife Sule Yasar BilgeCengiz Korkmaz
Nov 15, 2013·Current Opinion in Rheumatology·Alison Clifford, Gary S Hoffman
Feb 18, 2016·Autoimmunity Reviews·Y FerfarD Saadoun
Sep 19, 2015·La Revue de médecine interne·G PazzolaC Salvarani
Dec 14, 2011·Autoimmunity Reviews·Cloé ComarmondDavid Saadoun
Dec 14, 2011·Reumatología clinica·Mariano Arturo Díaz-Orta, Jorge Rojas-Serrano
May 1, 2010·Reumatología clinica·Cándido Díaz-LagaresManuel Ramos-Casals
Jun 30, 2009·The Journal of Pediatrics·Wael El-Matary, Rabin Persad
Jan 6, 2009·Journal of the American Academy of Dermatology·Samer GhosnImad Uthman
Apr 26, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·R GruberN Sepp
Oct 17, 2015·Rheumatology·Daiki Nakagomi, David Jayne
May 23, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Sara SternMaria Teresa Terreri
May 4, 2013·Annals of Vascular Diseases·Hidehiro Yamada
Jan 31, 2012·Medical Hypotheses·Diana Castillo-Martínez, Luis M Amezcua-Guerra
Aug 28, 2013·Seminars in Arthritis and Rheumatism·Lucía Silva-FernándezUNKNOWN Systemic Autoimmune Diseases Study Group of the Spanish Society for Rheumatology (EAS-SER)
Feb 19, 2013·International Journal of Cardiology·Mitsuaki Isobe
Sep 13, 2017·International Journal of Clinical Practice·Rafael L PachecoRachel Riera
May 29, 2008·Nature Clinical Practice. Rheumatology·Carol A Langford
Jul 22, 2009·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Xue-mei LiXue-wang Li
Jul 14, 2020·Nephrology·Arghya ChattopadhyaySanjay Jain
Oct 31, 2009·La Revue de médecine interne·L Ben HassineN Khalfallah

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