Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy

Gastroenterology Research and Practice
Rogério S ParraOmar Féres

Abstract

Investigate the association between infliximab trough levels and quality of life in inflammatory bowel disease patients in maintenance therapy. We carried out a transversal study with inflammatory bowel disease patients in infliximab maintenance therapy. Infliximab trough levels were determined using a quantitative rapid test. Disease activity indices (partial Mayo Score and Harvey-Bradshaw Index) and endoscopic scores (endoscopic Mayo Score or Simple Endoscopic Score in Crohn's disease) were obtained. Quality of life was assessed using the Inflammatory Bowel Disease Questionnaire (IBDQ). Seventy-one consecutive subjects were included in the study (55 with Crohn's disease and 16 with ulcerative colitis). Drug levels were considered satisfactory (≥3 μg/mL) in 28 patients (39.4%) and unsatisfactory (<3 μg/mL) in 43 (60.6%). Satisfactory trough levels were associated with higher rates of clinical remission and mucosal healing. Higher trough levels were also associated with improved IBDQ scores, particularly regarding bowel symptoms, systemic function, and social function. Satisfactory trough levels of infliximab were associated with higher rates of clinical remission, mucosal healing, and improved quality of life in inflammatory b...Continue Reading

References

Nov 3, 2011·The Journal of Rheumatology. Supplement·Philip JacobsLyn C Guenther
Jun 12, 2013·Journal of Crohn's & Colitis·Mike van der HaveHerma H Fidder
Sep 24, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Walter ReinischFreddy Cornillie
Mar 1, 2015·Gastroenterology·Niels Vande CasteeleSéverine Vermeire
Aug 11, 2016·Alimentary Pharmacology & Therapeutics·J AfonsoUNKNOWN Portuguese IBD Study Group (GEDII)

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Citations

Jun 14, 2020·The Journal of Applied Laboratory Medicine·Adriano TaddeoMarc E Pfeifer
Aug 18, 2020·European Journal of Clinical Pharmacology·Mihika B DaveTester F Ashavaid
Oct 23, 2019·World Journal of Gastroenterology : WJG·Rogerio S ParraMaria L A Ferrari
Oct 30, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Mihika B DaveTester F Ashavaid

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Methods Mentioned

BETA
blood collection

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SPSS
SPSS® Statistics

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