Infliximab Trough Levels at Induction to Predict Treatment Failure During Maintenance

Inflammatory Bowel Diseases
Claire LiefferinckxDenis Franchimont

Abstract

Infliximab (IFX) is indicated for the treatment of inflammatory bowel diseases (IBD). Nevertheless, loss of response (LOR) to IFX is reported in up to 10% to 30% of patients within the first year of treatment. Our objective was to evaluate the impact of the pharmacokinetics of IFX at induction on treatment failure. This is a longitudinal cohort study on 269 patients with IBD treated with IFX in a single center. A total of 2331 blood samples were prospectively collected from 2007 until March 2015 with a retrospective analysis of clinical data. IFX trough levels (TLs) were measured by enzyme-linked immunosorbent assay. Antibodies to IFX were measured by drug-sensitive bridging assay. During follow-up, patients were defined according to treatment outcome. At week 6, median IFX TL in patients requiring a switch to another treatment due to LOR (LOR switched group) (2.32 μg/mL [0.12-19.93 μg/mL]) was lower than in patients with long-term response (long-term responders) (8.66 μg/mL [0.12-12.09 μg/mL], P = 0.007) and in patients responding to optimization (LOR optimized group) (7.28 μg/mL [0.17-14.91 μg/mL], P = 0.021). At week 2, median IFX TL was lower in the LOR switched group (5.7 μg/mL [0.15-12.09 μg/mL]) compared with the long-te...Continue Reading

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Citations

Nov 22, 2017·Nature Reviews. Rheumatology·Joachim R Kalden, Hendrik Schulze-Koops
Jan 24, 2019·European Journal of Gastroenterology & Hepatology·Claire LiefferinckxDenis Franchimont
Jan 12, 2019·Journal of Pediatric Gastroenterology and Nutrition·Karen van HoeveSéverine Vermeire
Jun 11, 2019·Expert Opinion on Drug Metabolism & Toxicology·Raffaella FrancaGabriele Stocco
Feb 16, 2019·Journal of Pediatric Gastroenterology and Nutrition·Kathryn ClarkstonPhillip Minar
Jun 29, 2018·Archives of Disease in Childhood·Christopher J BurgessPeter J Lewindon
Jun 25, 2019·Journal of Pediatric Gastroenterology and Nutrition·Kathryn ClarkstonPhillip Minar
Feb 2, 2020·International Journal of Clinical Pharmacy·Mayte Gil-CandelCarles Iniesta-Navalón
Apr 7, 2018·Current Gastroenterology Reports·Nicholas CarmanEric I Benchimol
Mar 31, 2021·Inflammatory Bowel Diseases·Claire LiefferinckxDenis Franchimont

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