Sep 9, 2005

Infliximab use in Crohn's disease: impact on health care resources in the UK

European Journal of Gastroenterology & Hepatology
Derek JewellScot Buchan

Abstract

To quantify the impact of infliximab therapy on health care resource utilization in the UK. A retrospective audit was undertaken at seven centres in the UK, which reviewed patient notes for a period of 6 months before and 6 months after an initial infliximab infusion. Details of hospital admissions, outpatient visits, operations, diagnostic procedures, drug usage, and overall efficacy were collected. Results were compared for the two 6 month study periods. A total of 205 patients (62% female, median age 33 years) with moderate/severe Crohn's disease were audited. The majority of patients had chronic active disease (62%) and most received one infusion initially (72%). Clinicians rated 74% of responses as good to excellent and patients 72%. Most patients had concomitant immunosuppression (pre: 75%, post: 75%). Approximately half of the patients (45%) stopped taking steroids, with a further 34% having a dosage reduction. A fall of 1093 inpatient days was seen (1435 vs. 342) in the 6 months following infliximab administration. There were seven fewer operations, 33 fewer examinations under anaesthetic, and 99 fewer diagnostic procedures. Outpatient visits were similar pre- versus post- (555 vs. 534). The total reduction in direct co...Continue Reading

  • References17
  • Citations47

Citations

Mentioned in this Paper

Monoclonal Antibodies
IIeocolitis
Antirheumatic Drugs, Disease-Modifying
Decreased Immunologic Activity [PE]
Tumor Necrosis Factor-alpha
Action Research
Hospitalization
Cost Effectiveness
Diagnostic Procedure
Outpatients

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