Abstract
In order to improve calcium and phosphorus balance, beef cattle and dairy cows can be supplemented with vitamin D. However, different vitamin D metabolites have been shown to increase expression of P-glycoprotein (P-gp, MDR1, ABCB1) and cytochrome P450 3A (CYP3A) in rodents as well as in cell culture systems. As such interferences might have an impact on pharmacokinetics of some drugs widely-used in veterinary medicine, we investigated the expression of P-gp, CYP3A, vitamin D receptor (VDR), pregnane X receptor (PXR) and retinoid X receptor α (RXRα) in sheep either treated orally with 6μg/kg body weight (BW) 25-hydroxyvitamin D3 (OHD3) for ten days before sacrifice or 12h after intravenous injection of 0.5μg/kg BW 1,25-dihydroxyvitamin D3 (1,25- (OH)2D3). Down-regulation of ruminal, jejunal and hepatic, but not renal P-gp could be found with 25-OHD3 supplementation. Interestingly, this effect on P-gp was not observed in tissues from 1,25-(OH)2D3-treated sheep. In contrast, 1,25-(OH)2D3 induced a significant up-regulation of renal and jejunal CYP3A expression, while 25-OHD3 had no impact. Renal expression of VDR and PXR was also increased by treatment with 1,25-(OH)2D3, while jejunal PXR expression was only stimulated in sheep s...Continue Reading
References
May 7, 1976·Analytical Biochemistry·M M Bradford
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F ThiebautM C Willingham
Jul 1, 1967·Analytical Biochemistry·B C Sarkar, U P Chauhan
May 20, 1999·Annual Review of Pharmacology and Toxicology·F P Guengerich
Jun 21, 2001·Molecular Cell Biology Research Communications : MCBRC·M SukhaiM Piquette-Miller
Dec 10, 2002·Biochemical and Biophysical Research Communications·Paul D ThompsonMark R Haussler
Nov 7, 2003·Journal of Pharmaceutical Sciences·Gigi Lee, Micheline Piquette-Miller
Mar 9, 2004·The Journal of Pharmacology and Experimental Therapeutics·T MatsubaraY Yamazoe
May 12, 2005·Toxicology and Applied Pharmacology·Miriam N JacobsSteven R Hood
Jun 14, 2006·Biochemical Pharmacology·Yang XuKenneth E Thummel
Jun 9, 2007·The Journal of Biological Chemistry·Mark B MeyerJ Wesley Pike
Nov 14, 2007·BMC Evolutionary Biology·Erica J ReschlyMatthew D Krasowski
Jul 8, 2008·Biochemical Pharmacology·Mayumi SaekiRyuichi Hasegawa
Jul 22, 2008·The Veterinary Journal·Adrian LifschitzCarlos Lanusse
Aug 15, 2008·The Veterinary Journal·Mirja R WilkensBernd Schröder
Aug 30, 2008·Clinical Pharmacology and Therapeutics·J B Schwartz
Nov 22, 2008·Biochemical Pharmacology·Michela CantielloMauro Dacasto
Jan 14, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Christian ZimmermannAlfred H Schinkel
Sep 16, 2009·Biopharmaceutics & Drug Disposition·Edwin C Y ChowK Sandy Pang
Dec 8, 2009·Domestic Animal Endocrinology·M R WilkensB Schröder
Jan 1, 2010·Journal of Agricultural and Food Chemistry·Mery GiantinMauro Dacasto
Oct 23, 2010·Archives of Biochemistry and Biophysics·Hector F DelucaLori A Plum
Nov 11, 2010·Journal of Veterinary Pharmacology and Therapeutics·V ZancanellaE Negrisolo
Feb 26, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jonatan D LindhLinda Björkhem-Bergman
Mar 23, 2011·The Journal of Pharmacology and Experimental Therapeutics·Edwin C Y ChowK Sandy Pang
Dec 24, 2011·Journal of Dairy Science·M R WilkensG Breves
Jul 11, 2012·Animal Reproduction Science·O J Ginther, M A Beg
Jan 22, 2013·Pharmacology & Therapeutics·Ulrich M Zanger, Matthias Schwab
Apr 22, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·I S Haslam, N L Simmons
Aug 27, 2014·Genetics and Molecular Research : GMR·M Yan, H Nuriding
Jan 4, 2015·Chemico-biological Interactions·Lucie StuchlíkováLenka Skálová
May 29, 2015·Journal of Animal Science·G HermM R Wilkens
Citations
Jan 16, 2018·Physiological Reports·Stefanie KlingerJens Herrmann
May 22, 2018·Frontiers in Pharmacology·Tingting GuoLiping Wang
Apr 22, 2019·Journal of Dairy Science·Michelle L HydeDavid R Fraser
Oct 2, 2020·Journal of Animal Physiology and Animal Nutrition·Oriana M KöhlerMirja R Wilkens
Mar 5, 2020·Expert Review of Clinical Pharmacology·Ricardo Blanco-CastañedaMartha Sosa-Macías