Influence of 4-week multi-strain probiotic administration on resting-state functional connectivity in healthy volunteers

European Journal of Nutrition
Deepika BaggaVeronika Schöpf

Abstract

Experimental investigations in rodents have contributed significantly to our current understanding of the potential importance of the gut microbiome and brain interactions for neurotransmitter expression, neurodevelopment, and behaviour. However, clinical evidence to support such interactions is still scarce. The present study used a double-blind, randomized, pre- and post-intervention assessment design to investigate the effects of a 4-week multi-strain probiotic administration on whole-brain functional and structural connectivity in healthy volunteers. Forty-five healthy volunteers were recruited for this study and were divided equally into three groups (PRP: probiotic, PLP: placebo, and CON: control). All the participants underwent resting-state functional MRI and diffusion MRI brain scans twice during the course of study, at the beginning (time point 1) and after 4 weeks (time point 2). MRI data were acquired using a 3T whole-body MR system (Magnetom Skyra, Siemens, Germany). Functional connectivity (FC) changes were observed in the default mode network (DMN), salience network (SN), and middle and superior frontal gyrus network (MFGN) in the PRP group as compared to the PLP and CON groups. PRP group showed a significant dec...Continue Reading

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Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
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Linear Image Registration Tool ( FLIRT )
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FMRI Expert Analysis Tool ( FEAT )
MELODIC
DTIFIT
FNIRT
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FMRIB

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