PMID: 22580528May 15, 2012Paper

Influence of 825 C>T polymorphism of G protein β3 subunit gene (GNB3) on hemodynamic response during dobutamine stress echocardiography

Pharmacological Reports : PR
Anna BanaśMarek Droździk

Abstract

There is a wide interpersonal difference to dobutamine response during dobutamine stress echocardiography (DSE). The aim of this study was to determine an association between GNB3 825C>T gene polymorphism, encoding the β3-subunit of G protein, and heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP) response to dobutamine during DSE. The study involved 119 patients with clinical indications for DSE. Genotyping of GNB3 825C>T (rs5443) polymorphism was based on PCR-RFLP method with BseDI restriction enzyme. Significantly higher levels of both resting SBP and DBP in 825T allele carriers vs. 825CC patients were revealed. HR of 825CC vs. CT + TT subjects was slower along the test period reaching marked difference at dobutamine level 30 μg/kg/min (109 ± 20 vs. 116 ± 18 bpm, respectively, p = 0.047). SBP and DBP were markedly lower in 825CC homozygotes compared to 825T allele carriers throughout DSE. It can be concluded that GNB3 825C>T polymorphism is associated with resting SBP and DBP in Polish Caucasian patients subjected for diagnostic DSE. The polymorphism also modulate HR, SBP and DBP response during DSE.

References

May 15, 1997·The American Journal of Cardiology·A L DalyM A Supiano
Jan 13, 1998·Nature Genetics·W SiffertB Horsthemke
Apr 30, 1998·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T J LewandowskiD S Bach
Jul 12, 2002·Clinical and Experimental Hypertension : CHE·Esteban PochAlejandro de la Sierra
Aug 25, 2004·The American Journal of Cardiology·Christina L AquilanteJulie A Johnson
Jun 23, 2009·Journal of Clinical Pharmacology·Yan-Mei MaoHong-Hao Zhou

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Citations

Nov 5, 2015·Drug Metabolism Reviews·Marwa OunissiStéphanie Chhun
Nov 27, 2019·Journal of Molecular Neuroscience : MN·Maria PapasavvaNikolaos Drakoulis

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