PMID: 15374200Nov 1, 1995Paper

Influence of a double blind pharmacological trial on two domains of well-being in subjects with age associated memory impairment

Archives of Gerontology and Geriatrics
M NeriG Salvioli

Abstract

This random double-blind trial compares psychological well-being and perceived quality of life in 60 subjects (18 M, 42 F), mean age 61 years, with age-associated memory impairment (AAMI), who were administered a standardised ginseng-containing vitamin complex or placebo for 9 months. We evaluated psychological well-being, in terms of affective status and memory functioning using the Symptom Rating Test [SRT] (depression, anxiety, somatisation, inadequacy) and Randt Memory Test [RMT] (memory index [MI]), respectively, and the quality of life, using the Life Satisfaction in the Elderly Scale [LSES]. At final evaluation, SRT did not differ in the drug and placebo groups, whereas MI and LSES were significantly higher in the drug-treated group. Moreover, the negative correlation between the affective (SRT) and cognitive (MI) component of psychological well-being waned in the drug-treated but not placebo group. In the drug-treated group, a positive correlation emerged between the cognitive index and social contacts, mood and self-concept factors of the LSES. In both groups, the initial negative correlations between quality of life (LSES) and affection (SRT) persisted at the end of the study. Drug-treated AAMI subjects differ from co...Continue Reading

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Citations

Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·David O Kennedy, Andrew B Scholey
Jul 1, 2014·Child and Adolescent Psychiatric Clinics of North America·Charles W Popper
Feb 28, 2003·Journal of Clinical Pharmacy and Therapeutics·C I ColemanP Reddy
Dec 15, 2010·The Cochrane Database of Systematic Reviews·Jinsong GengReem Malouf
Oct 18, 2006·International Journal of Geriatric Psychiatry·Martine MolJelle Jolles
Jan 29, 2019·The American Journal of Hospice & Palliative Care·Mellar P Davis, Bertrand Behm
Nov 5, 2003·American Family Physician·David Kiefer, Traci Pantuso
Dec 21, 2012·Expert Review of Neurotherapeutics·Julia J Rucklidge, Bonnie J Kaplan
May 22, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joanna Thompson Coon, Edzard Ernst
Mar 16, 2002·The Annals of Pharmacotherapy·Jennifer M Ellis, Prabashni Reddy

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