Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model

Asian Journal of Surgery
Mohammad GolrizMarta M Gebhard

Abstract

Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidine-tryptophane ketoglutarate (HTK-N) solution has been designed and its protective efficacy was compared with the standard preservation solutions-University of Wisconsin solution and standard HTK or Custodiol (Bretschneider's solution). Seventy-two landrace pigs were included into the study, as donors and recipients. The donor kidneys were perfused during explantation with cold University of Wisconsin solution (n = 12), standard HTK (n = 12), or HTK-N solutions (n = 12), kept in the respective preservation solution at 4°C for 30 hours, implanted in the recipient pigs, and reperfused. The pigs survived in daily control for 7 days. The serum creatinine and blood urea nitrogen were assessed in pre- and postreperfusion phase on the 3rd day and 7th day posttransplantation. Additionally, tissue samples were taken to analyze the histopathological degree of tubular injury and regeneration before and after reperfusion. The three preservation groups were comparable in age, body weight, and hemodynamic parameters...Continue Reading

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Citations

Nov 17, 2017·American Journal of Physiology. Renal Physiology·Lei WangRuisheng Liu
Jun 24, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mohammad GolrizArianeb Mehrabi
Sep 10, 2020·International Journal of Molecular Sciences·Annika MohrFelix Becker
Oct 25, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shadan LiCaigan Du
Jan 28, 2021·Acta Cirúrgica Brasileira·Jacob Hindrik Antunes SmitAdenauer Marinho de Oliveira Góes Junior
Apr 3, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Samara Guilhermina de SousaMarcus Vinicius Henriques Brito

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