Influence of a new monofilament polyester mesh on inflammation and matrix remodeling

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Phuoc T NguyenLisa M Pierce

Abstract

ABSTRACT Synthetic mesh is widely used for hernia repairs, but mesh-induced chronic inflammatory responses may lead to postoperative complications. We previously showed an elevated response to multifilament polyester (PE) versus monofilament polypropylene (PP) and polytetrafluoroethylene (PTFE) meshes, but it is unclear whether this discrepancy is due to the differences in chemical composition or filament structure. This study compares the influence of a newly available monofilament PE mesh to that of multifilament PE, monofilament PP, and monofilament PTFE on the expression of genes important in inflammation and extracellular matrix remodeling in a rat model. Full thickness abdominal wall defects were corrected with onlay repair or suture repair with no mesh. Explants were harvested 7 or 90 days after repair and divided for histology and mRNA analyses using real-time quantitative polymerase chain reaction arrays to profile expression at the tissue-mesh interface. Monofilament PE elicited a reduced foreign body reaction compared to multifilament PE, corresponding with reduced mRNA expression of important inflammatory cytokines and matrix metalloproteinases (MMPs). Unexpectedly, monofilament PE also resulted in markedly reduced ...Continue Reading

References

Jul 1, 1996·The British Journal of Dermatology·M VaalamoU K Saarialho-Kere
Apr 29, 1998·American Journal of Surgery·E GürleyikS Unalmiser
Feb 24, 1999·The European Journal of Surgery = Acta Chirurgica·U KlingeV Schumpelick
Feb 24, 1999·The European Journal of Surgery = Acta Chirurgica·U KlingeV Schumpelick
Aug 19, 1999·The European Journal of Surgery = Acta Chirurgica·U KlingeV Schumpelick
Aug 10, 2000·The British Journal of Surgery·UNKNOWN EU Hernia Trialists Collaboration
Aug 10, 2000·The New England Journal of Medicine·R W LuijendijkJ Jeekel
Jan 5, 2002·Hernia : the Journal of Hernias and Abdominal Wall Surgery·G WeltyV Schumpelick
Mar 1, 2002·Journal of Biomedical Materials Research·U KlingeB Klosterhalfen
Mar 8, 2002·Annals of Surgery·UNKNOWN EU Hernia Trialists Collaboration
Apr 2, 2002·The Journal of Surgical Research·Stephen BadylakRobert Morff
Sep 5, 2002·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A M Grant, UNKNOWN EU Hernia Trialists Collaboration
Sep 26, 2002·World Journal of Surgery·Karsten JungeVolker Schumpelick
Jan 25, 2003·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·K JungeV Schumpelick
Apr 23, 2005·Surgical Innovation·William S CobbB Todd Heniford
Oct 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Maja L KonstantinovicJan A Deprest
Aug 21, 2007·Seminars in Cell & Developmental Biology·Anne M Manicone, John K McGuire
Sep 12, 2007·Hernia : the Journal of Hernias and Abdominal Wall Surgery·J R EriksenJ Rosenberg
Dec 29, 2007·Seminars in Immunology·James M AndersonDavid T Chang
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic
Dec 17, 2009·Surgery·Matthew J ReissWarren L Garner
May 27, 2010·Annals of the Royal College of Surgeons of England·C N Brown, J G Finch
Dec 1, 2010·Journal of the American College of Surgeons·Corey R DeekenBrent D Matthews
Feb 25, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jennifer R AsariasLisa M Pierce

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Citations

Apr 16, 2013·The Journal of Surgical Research·David P MartinJeffrey R Scott
Jun 16, 2014·The Journal of Surgical Research·Job C TharappelJ Scott Roth
Aug 2, 2014·Hernia : the Journal of Hernias and Abdominal Wall Surgery·William C ColeLisa M Pierce
Mar 25, 2014·Hernia : the Journal of Hernias and Abdominal Wall Surgery·C C PetroM J Rosen
Apr 27, 2016·Clinical and Experimental Pharmacology & Physiology·Ziya T OzkececiBahadir Celep

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