PMID: 8600965Mar 1, 1996Paper

Influence of a non-ionic radiography contrast medium on the microcirculation

Acta Radiologica
R BachH Schieffer

Abstract

PURPOSE, MATERIAL AND METHODS: Microcirculatory disturbances may be responsible for some of the adverse effects induced by contrast media. The influence of iopromide 370 (Ultravist) on cutaneous microcirculation was therefore investigated in 15 patients in a prospective study. Twenty ml of iopromide and 20 ml 0.9% NaCl were injected as reference in the subclavian artery at the beginning of a diagnostic coronary angiography. Erythrocyte velocity was measured in ipsilateral nailfold capillaries at the beginning of, during, and after the injection continuously up to 6 min after injection. On average, 30 s after injection of contrast medium, erythrocyte velocity decreased significantly by 51.3% (p<0.0001) and remained reduced up to 120 s. This reaction was observed in 14 out of 15 patients. Three patients showed a temporary cessation of capillary blood flow. The adverse effects sometimes seen during coronary angiography can be explained if similar contrast medium induced microcirculatory disturbances in the myocardial vasculature.

References

Jan 1, 1978·Acta Radiologica: Diagnosis·P Aspelin, H Schmid-Schönbein
Sep 1, 1990·Biomedizinische Technik. Biomedical Engineering·F JungG Müller
Sep 1, 1987·Biomedizinische Technik. Biomedical Engineering·F JungG Müller
Aug 18, 1967·Science·S ChienM M Guest

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Citations

May 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·S MollR Dietz
May 29, 2003·Canadian Journal of Physiology and Pharmacology·Xuequn HuangAkio Sakanishi
Jan 28, 2017·Clinical Hemorheology and Microcirculation·F Jung, M Rampling

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