Influence of a superficial tangential zone over repairing cartilage defects: implications for tissue engineering

Biomechanics and Modeling in Mechanobiology
J R Owen, J S Wayne

Abstract

The superficial tangential zone (STZ) plays a critical role in normal cartilage function but is not yet a focus for designing tissue-engineered constructs for cartilage repair. Without material properties of sufficient quality in this zone, transplanted constructs in vivo may have little chance of survival. This finite element study investigates the impact of the superficial tangential zone on the mechanical function of normal articular surfaces as well as those with transplanted constructs. The zone is modeled as a thin transversely isotropic material with strain dependent permeability. The analyses predict that a normal transversely isotropic STZ placed over a repair region reduces the axial compression (55-68%) of, and the rate of fluid loss (45-82%) from the articular surface. A reduction was also found in von Mises stress (26-57%), axial strain (22-56%), and radial strain (69-73%), and an increase in fluid pressure (19-45%) in repair tissue under the STZ. Incorporating a quality superficial tangential zone in tissue-engineered constructs may be a critical factor in achieving mechanical environments conducive for successful cartilage repairs.

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Citations

Nov 4, 2006·Biomechanics and Modeling in Mechanobiology·Gerard A Ateshian
Aug 12, 2010·Biomechanics and Modeling in Mechanobiology·John R Owen, Jennifer S Wayne
May 23, 2008·Annals of Biomedical Engineering·Ashkan VaziriBashir A Tafti
Feb 22, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Mehdi KhoshgoftarKeita Ito
Aug 4, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Ali Vahdati, Diane R Wagner
May 18, 2013·Tissue Engineering. Part C, Methods·Mehdi KhoshgoftarCorrinus C van Donkelaar
Oct 28, 2011·Cell and Tissue Research·Linda KockKeita Ito
Mar 6, 2012·Biomechanics and Modeling in Mechanobiology·Mehdi KhoshgoftarCorrinus C van Donkelaar
Nov 20, 2012·Biomechanics and Modeling in Mechanobiology·Mehdi KhoshgoftarCorrinus C van Donkelaar
Dec 4, 2014·Journal of Biomechanics·Stephanie GrenierPeter A Torzilli
Sep 24, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Qingen MengAlison Jones
Jan 19, 2008·Medicine and Science in Sports and Exercise·Ajit M W ChaudhariThomas P Andriacchi
Mar 12, 2009·Journal of Biomechanical Engineering·Karin A Wartella, Jennifer S Wayne
Feb 6, 2020·Journal of Biomechanical Engineering·Jennifer S Wayne
May 11, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Homeyra PourmohammadaliJohn B Medley
Apr 18, 2019·Biomechanics and Modeling in Mechanobiology·Amin KomeiliWalter Herzog
Jun 5, 2020·Journal of medical and biological engineering·Mostafa MotavalliJean F Welter
Mar 20, 2021·Advanced Healthcare Materials·Jay M PatelRobert L Mauck
Aug 23, 2020·Journal of Biomechanics·Amin KomeiliWalter Herzog
Nov 23, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Yuqin SunWeiyi Chen

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