Influence of abiraterone acetate on circulating neuromediators in chemotherapy-naïve castration-resistant prostate cancer

The Prostate
Jost von HardenbergElmar Heinrich

Abstract

Abiraterone Acetate (AA) represents a highly effective androgen-receptor (AR) axis targeted agent. Treatment with AA in castration-resistant prostate cancer (CRPC) may partly mediate neuroendocrine differentiation (NED) as an escape mechanism, which may have implications for the choice of sequential therapy in CRPC. We evaluated how treatment with AA influences circulating neuromediators chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin-releasing peptide (Pro-GRP) in chemotherapy-naïve CRPC patients. We conducted an analysis in chemotherapy-naïve CRPC patients with clinical or radiographic progression of disease. A total of 35 patients were included at five institutions between February 2013 and December 2014. Sixteen of them had received AA. Serum samples were obtained before a docetaxel-based chemotherapy and analyzed in a reference laboratory. Univariable and multivariable analyses were performed to test the influence of AA treatment, its duration of treatment, and other clinicopathological variables on circulating neuromediators. CGA and NSE levels were above the upper limit of normal (ULN) in n = 20 (57.1%) and n = 13 (37.1%), respectively. Treatment with AA and duration of treatment were not associated ...Continue Reading

References

May 1, 1986·The New England Journal of Medicine·D T O'Connor, L J Deftos
Oct 29, 1998·British Journal of Cancer·E BaudinM Schlumberger
Apr 12, 2002·The Prostate·Hazem R Ismail ASimone Chevalier
Jun 11, 2005·Human Pathology·Rainer GrobholzUwe Bleyl
Nov 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anton StangelbergerCelia A Kanashiro
Feb 4, 2009·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Eiwa IshidaNoboru Konishi
Sep 18, 2009·The Prostate·Helmut Bonkhoff, Richard Berges
Sep 29, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Catharina M KorseJohannes M G Bonfrer
Mar 10, 2012·Clinical Genitourinary Cancer·Deliu-Victor MateiOttavio de Cobelli
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Himisha BeltranDavid M Nanus
Apr 16, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K L NoonanK N Chi
Nov 8, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yang LiuZhen Cheng
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 8, 2014·The American Journal of Surgical Pathology·Jonathan I EpsteinMark A Rubin
Apr 18, 2014·Endocrine-related Cancer·Salvatore Luca BurgioUgo De Giorgi
Jun 3, 2014·The New England Journal of Medicine·Tomasz M BeerUNKNOWN PREVAIL Investigators
Sep 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott T Tagawa
Oct 30, 2014·The New England Journal of Medicine·Tomasz M Beer, Bertrand Tombal
Mar 19, 2015·Frontiers in Oncology·Alexandru Dan GrigoreMary C Farach-Carson
Jul 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K L NoonanK N Chi

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