PMID: 6753997Sep 1, 1982

Influence of acetylator phenotype on antidepressant effects of phenelzine

The British Journal of Psychiatry : the Journal of Mental Science
E S PaykelR R Parker

Abstract

Acetylator phenotype, determined by blood levels after sulphadimidine, was related to outcome in a controlled trial of phenelzine in patients with depression and mixed anxiety depression. Slow acetylators showed more improvement and greater phenelzine-placebo differences than did fast acetylators, at two, four and six weeks. A tendency towards faster acetylation was observed in subjects with previous increased alcohol intake. Acetylator phenotype was not related to other symptom, diagnostic or history data.

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Citations

Jan 1, 1985·Journal of Psychiatric Research·C Shawcross, P Tyrer
Jan 1, 1988·Journal of Psychiatric Research·P Tyrer, C Shawcross
Jul 1, 1985·Journal of Affective Disorders·E S Paykel
Jun 8, 2002·Pharmacogenomics·Peter Meisel
May 7, 2002·The Pharmacogenomics Journal·N J ButcherR F Minchin
May 17, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Stephen C Mitchell
Sep 14, 2006·Pharmacological Reviews·Sharon J Gardiner, Evan J Begg
Jun 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·C M Pare
Jun 19, 2015·The Cochrane Database of Systematic Reviews·Mauricio Silva de LimaBernardo G O Soares

Related Concepts

Acetylation
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Clinical Trials
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Double-Blind Method
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