Influence of acetylsalicylic acid (aspirin) on biofilm production by Candida species

Journal of Chemotherapy
S StepanovićL Ranin

Abstract

Candida spp. are important causative agents of infections associated with biofilm formation. Management of biofilm-related infections is extremely difficult and therefore new therapeutic solutions are needed. This study for the first time explored the possible effect of aspirin on Candida spp. Biofilm-producing capacity. Two strains of C. guilliermondii, and one strain per species of C. kefyr, C. glabrata, C. albicans, and C. parapsilosis were included in the study. The antifungal property of aspirin was tested by the broth microdilution method, while effect of aspirin on biofilm formation was determined by the microtiter-plate test. The minimal inhibitory concentrations of aspirin obtained ranged from 2.17 to 8.67 mM and minimal fungicidal concentrations were from 4.33 to 8.67 mM. The concentrations of aspirin which induced statistically significant decrease in biofilm formation ranged from 0.43 mM to 1.73 mM of aspirin, depending on the tested yeast strain. Therefore, the significant effects of aspirin on growth and biofilm formation of Candida spp. were achieved only with suprapharmacological concentrations of the drug. The influence of the inoculum size on the effect of aspirin on biofilm formation was determined for C. alb...Continue Reading

References

Aug 1, 1995·Antimicrobial Agents and Chemotherapy·D P NicolauR Quintiliani
Feb 18, 1998·The Journal of Infectious Diseases·E MullerB F Farber
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·G S Baillie, L J Douglas
Apr 28, 2001·FEMS Microbiology Letters·R DevaS Nigam
Aug 15, 2001·Antimicrobial Agents and Chemotherapy·G RamageJ L López-Ribot
Apr 5, 2002·Clinical Microbiology Reviews·Rodney M Donlan, J William Costerton
Jun 1, 2002·The Journal of Antimicrobial Chemotherapy·Gordon RamageJosé L López-Ribot

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Citations

Jun 14, 2015·Expert Review of Anti-infective Therapy·Kaat De CremerKatrijn De Brucker
Jul 11, 2016·Revista iberoamericana de micología·José Luis Del Pozo, Emilia Cantón
Mar 1, 2018·Frontiers in Medicine·Mafalda Cavalheiro, Miguel Cacho Teixeira
Dec 14, 2004·Yeast
Feb 1, 2017·Antimicrobial Agents and Chemotherapy·Petra Zimmermann, Nigel Curtis
Feb 15, 2019·Journal of Chemotherapy·Peral JoséRafael Zaragoza
Jan 1, 2020·International Journal of Nursing Knowledge·Renan Alves SilvaAna Railka Oliveira-Kumakura
Nov 10, 2012·The International Journal of Artificial Organs·Melania IñigoJose L Del Pozo
Apr 9, 2005·Microbiology·Sean F Laffey, Geraldine Butler
Apr 24, 2021·Infection and Drug Resistance·Alice Kit Ying ChanChiu Shun Peter Tsang
Jul 18, 2015·Microbiology Spectrum·Christopher G PierceJosé L López-Ribot
Aug 14, 2021·Frontiers in Microbiology·Rodrigo Cuiabano Paes Leme, Raquel Bandeira da Silva

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