Influence of acid aerosol droplet size on structural changes in the rat lung caused by acute exposure to sulfuric acid and ozone

Toxicology and Applied Pharmacology
T A KimmelC Nadziejko

Abstract

To investigate whether aerosol droplet size influences structural changes in the lung produced by short-term, concomitant exposure to ozone and sulfuric acid, groups of 10 rats were exposed 4 hr/day for 2 days to filtered air, 0.6 ppm ozone, 0.5 mg/m3 fine (aerosol mass median diameter (MMD) = 0.3 microm) or ultrafine (MMD = 0.06 microm) sulfuric acid, or a mixture of ozone and 0.5 mg/m3 fine or ultrafine sulfuric acid. The volume percentage of total parenchyma containing markedly to severely injured alveolar septae was measured morphometrically. There were no differences between the ultrafine or fine acid exposure groups and the sham group for any of the morphologic endpoints. Volume percentage of markedly to severely injured tissue was increased in the ultrafine, but not fine, mixture animals when compared with the ozone-only group. In addition, a synergistic interaction between ozone and ultrafine, but not fine, sulfuric acid was found for this endpoint. The bromodeoxyuridine cell labeling index in the periacinar region was greater in the rats exposed to the fine sulfuric acid and ozone mixture than that in rats exposed to ozone alone, and a synergistic interaction between ozone and fine sulfuric acid was found for this end ...Continue Reading

Citations

Jan 24, 2009·Environmental Health Perspectives·Joe L Mauderly, Jonathan M Samet
Dec 23, 1998·Environmental Health Perspectives·V J FeronJ P Groten
Feb 23, 2002·Toxicology and Applied Pharmacology·Bellina VeronesiMarga Oortgiesen
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M OortgiesenS A Simon
Nov 3, 2011·Chemical Reviews·Renyi ZhangWen Xu

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