PMID: 3966542Jan 1, 1985

Influence of acidosis on AMP deaminase activity in contracting fast-twitch muscle

The American Journal of Physiology
G A Dudley, Ronald L Terjung

Abstract

The rate of AMP deamination to IMP and NH4, by the action of AMP deaminase, is increased in vitro by acidosis and elevations in [AMP] and [ADP]. We evaluated the influence of acidosis on the activity of AMP deaminase in contracting muscle (5 Hz) by relating the time course of IMP and NH4 production to lactate-induced acidosis in low-oxidative, fast-twitch white (FTW) and high-oxidative, fast-twitch red (FTR) muscle of the rat. Cellular acidosis was modified by controlling lactic acid accumulation by regulating muscle blood flow and using trained animals. A significant activation of AMP deaminase occurred in both muscle types, but only at times when the estimated pH was 6.6 and below (lactate content 20 mu mol/g and above). Cellular acidosis, however, is not absolutely essential, since iodoacetic acid-blocked muscle lost 85-90% of its ATP to IMP during contractions. Thus cellular acidosis seems to be an important, but not the sole, factor activating AMP deaminase during contractions. Further, the influence of acidosis is probably different between fiber types, since the estimated free AMP and ADP contents, calculated from the creatine kinase and myokinase reactions, were different in the two fiber types. Most of the activation o...Continue Reading

Citations

Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·D A Sewell, R C Harris
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·D CzarnowskiJ Górski
May 16, 1997·The Journal of Biological Chemistry·D VavvasN B Ruderman
Oct 24, 1998·The Journal of Biological Chemistry·M D RokawJohn P Johnson
Sep 10, 1999·The Journal of Biological Chemistry·J D StockandJ P Johnson
Dec 10, 1999·The Journal of Biological Chemistry·J D StockandD C Eaton
Feb 13, 2001·Journal of Applied Physiology·B M PriorR A Meyer
Jan 22, 2005·American Journal of Physiology. Cell Physiology·Chad R HancockRonald L Terjung
Dec 17, 2008·Journal of Applied Physiology·Adam J Rose, Erik A Richter
Dec 5, 2009·Journal of Applied Physiology·G Nathan NakkenWilliam W Winder
Mar 1, 1987·Archives internationales de physiologie et de biochimie·P K MohanK Indira
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·R C HarrisR A Harkness
Aug 1, 1995·Canadian Journal of Physiology and Pharmacology·E R ChinP J O'Brien
May 1, 1988·Biological Reviews of the Cambridge Philosophical Society·A van Waarde
Feb 27, 2004·American Journal of Physiology. Cell Physiology·Kirk A AbrahamRonald L Terjung
Apr 5, 2000·The Journal of Biological Chemistry·A BecchettiD C Eaton
Sep 17, 2002·Research Quarterly for Exercise and Sport·T OhkuwaYuzo Sato
Oct 31, 2002·Equine Veterinary Journal. Supplement·A N KavazisE A Ott
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·H J GreenA R Tupling
Nov 4, 2008·Journal of Strength and Conditioning Research·Moh H MalekDona J Housh
Sep 30, 2005·European Journal of Applied Physiology·Takahide KatoNobuo Matsui
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·H Itoh, T Ohkuwa
Feb 14, 2006·The Journal of Biological Chemistry·Robert S EdingerJohn P Johnson
Oct 1, 2005·Journal of Applied Physiology·Chad R HancockRonald L Terjung
Jan 28, 1999·The Journal of Biological Chemistry·J D StockandD C Eaton
Feb 6, 2010·Journal of Applied Physiology·Pengxiang SheChristopher J Lynch
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Vladimir Ljubicic, David A Hood
Sep 24, 2005·Medicine and Science in Sports and Exercise·Surendran SabapathyNorman R Morris
Apr 17, 2014·Journal of Strength and Conditioning Research·Esteban M GorostiagaMikel Izquierdo
Nov 12, 2015·Pharmacogenomics·Rayan SaabRolf P Kreutz
Mar 30, 2016·The Journal of General Physiology·Thomas Holm PedersenOle Bækgaard Nielsen
Mar 5, 1998·The American Journal of Physiology·J W RushRonald L Terjung
Jan 1, 1995·Muscle & Nerve. Supplement·I Mineo, S Tarui
May 18, 1999·The American Journal of Physiology·R BergeronG I Shulman
Mar 3, 2004·Journal of Applied Physiology·Kirk A Abraham, Ronald L Terjung
Feb 23, 1996·The Journal of Biological Chemistry·M D RokawJohn P Johnson
Oct 12, 1999·The American Journal of Physiology·M G Hollidge-HorvatG J Heigenhauser
Aug 9, 2002·The Journal of Biological Chemistry·Warren G HillJohn P Johnson
Oct 27, 2005·American Journal of Physiology. Endocrinology and Metabolism·Taro ToyodaTatsuya Hayashi
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·P L GreenhaffM Dunnett
Aug 5, 2000·Research Quarterly for Exercise and Sport·Y Yuan, K M Chan
Jul 1, 1990·Acta Physiologica Scandinavica·J M RenE Hultman
Aug 1, 1987·Clinical Physiology·E JanssonP A Tesch
Dec 14, 2011·Journal of Applied Physiology·Jacek Zielinski, Krzysztof Kusy

Related Concepts

Metabolic Acidosis
Adenine Nucleotides
AMP Deaminase
Electric Stimulation Technique
Energy Metabolism
Sodium Inosinate
Ischemia
Inotropism
Muscle
Nucleotide Deaminases

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

Related Papers

The American Journal of Physiology
G A Dudley, Ronald L Terjung
The American Journal of Physiology
D M Whitlock, Ronald L Terjung
© 2021 Meta ULC. All rights reserved