Influence of adiponectin gene polymorphisms on adiponectin level and insulin resistance index in response to dietary intervention in overweight-obese patients with impaired fasting glucose or newly diagnosed type 2 diabetes.

Diabetes Care
Hye Kyung ChungJong Ho Lee

Abstract

The aim of this study was to determine the effect of common adiponectin gene polymorphisms on dietary intervention-mediated changes in adiponectin levels and homeostasis model assessment of insulin resistance (HOMA-IR) indexes. A total of 363 subjects with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes followed a dietary intervention (replacement of cooked refined rice with whole grains and an increase in vegetable intake) and regular walking for 12 weeks without any medication. Adiponectin gene single nucleotide polymorphisms (SNPs) (45, 276, and -11377) were examined in these subjects. After this dietary intervention, fasting glucose levels decreased in all three SNP 45T>G genotype groups. Subjects with the SNP 45TT genotype showed increased adiponectin levels and decreased HOMA-IR indexes. Haplotype analysis revealed that homozygous carriers of the TG haplotype (45TT and 276GG) and heterozygous carriers of the TG haplotype (TG/X) showed a reduction in the HOMA-IR index after adjustment for baseline levels. Significant differences were observed in changes in HOMA-IR indexes and adiponectin concentrations according to the 45-276 TG haplotype in overweight-obese, but not in normal-weight subjects: the greates...Continue Reading

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Citations

Apr 5, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Kyoung Ae KongYoung Ju Kim
Jan 1, 2012·Journal of Diabetes and Metabolic Disorders·Shirin Hasani-RanjbarElnaz Abbasifarid
Jun 28, 2013·Journal of Human Hypertension·J S R MachadoR C Cavalli
Sep 27, 2013·Archives of Gynecology and Obstetrics·Olga BeltchevaIliana Atanasova
Oct 1, 2009·Diabetes/metabolism Research and Reviews
May 20, 2015·Biological Trace Element Research·Ana Raquel Soares de OliveiraDilina do Nascimento Marreiro
Aug 5, 2020·Reproductive Sciences·Wael BahiaWassim Y Almawi
Aug 13, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Mi SuYongyan Song

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