Influence of adiposity in the blunted whole-body protein anabolic response to insulin with aging

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Stéphanie ChevalierJosé A Morais

Abstract

Although insulin resistance of glucose is often reported with aging, that of protein metabolism is still debated. We tested if the insulin sensitivity of protein metabolism parallels that of glucose and is altered with aging. Whole-body (13)C-leucine and (3)H-glucose kinetics were measured in the postabsorptive state and during an hyperinsulinemic, euglycemic, isoaminoacidemic clamp in 12 young men (age: 27 +/- 1 years; body mass index [BMI]: 23 +/- 1 kg/m(2)), 11 young women (age: 25 +/- 1 years; BMI: 21 +/- 1 kg/m(2)), 9 elderly men (age: 70 +/- 1 years; BMI: 26 +/- 1 kg/m(2)), and 10 elderly women (age: 69 +/- 2 years; BMI: 23 +/- 1 kg/m(2)). Postabsorptive leucine flux rates adjusted for fat-free mass (FFM) were not different between elderly and young participants. During the clamp, leucine flux and protein synthesis rates increased less in the elderly participants, and protein breakdown decreased equally. Thus, the net anabolic (protein balance) response to hyperinsulinemia was lower in elderly versus young participants (p =.007) and was highly correlated with the clamp glucose rate of disposal (r = 0.671, p <.001), indicating insulin resistance of protein concurrent with that of glucose. From regression analysis, FFM expl...Continue Reading

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Citations

Nov 14, 2013·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jihye BaekJaehoon Roh
Dec 2, 2008·Journal of Nutrition for the Elderly·Andrea R JosseCyril W C Kendall
May 17, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Annemarie KosterUNKNOWN Health ABC study
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Feb 1, 2013·The American Journal of Clinical Nutrition·Kristen M BeaversStephen B Kritchevsky
May 30, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stéphanie Chevalier, Samaneh Farsijani
Jun 1, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Aaron WinterStéphanie Chevalier
Jun 13, 2015·Experimental Gerontology·Jessica MurphyJosé A Morais
Mar 11, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stuart M PhillipsHeather J Leidy
Oct 18, 2007·Diabetes·Sandra PereiraRéjeanne Gougeon
Oct 3, 2008·La Revue de médecine interne·Y Rolland, B Vellas
Oct 23, 2012·Biological Research for Nursing·Oleg ZaslavskyAndrea LaCroix
Mar 26, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stéphanie ChevalierJosé A Morais
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Eric D B GouletIsabelle J Dionne
Jul 29, 2016·The American Journal of Clinical Nutrition·Samaneh FarsijaniStéphanie Chevalier
Dec 22, 2017·Journal of the Endocrine Society·Cherise C LabonteStéphanie Chevalier
Aug 14, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David L WilliamsonJacob M Haus
Sep 15, 2017·Journal of Cachexia, Sarcopenia and Muscle·Daniel S RooksLászló B Tankó

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