[Influence of adjuvant pain medication on quality of life in the treatment of postmenopausal osteoporosis].

Der Orthopäde
D KrockerC Perka

Abstract

Chronic pain is the main symptom of postmenopausal osteoporosis. This can decrease mobility and quality of life of the patients. The hypothesis of this study was that administration of an adjuvant pain medication is essential additionally to the basic therapy. The second question was if a recommendation can be formulated whether a peripheral or a central acting pain medication is more effective to prevent osteoporosis induced chronic pain. Three pseudorandomised patient groups were prospectively compared. Group 1 was treated with alendronate, vitamin D, and calcium. Group 2 also received ibuprofen, and group 3 also received tramadol. In 117 women suffering from postmenopausal osteoporosis, quality of life was measured before and 26 weeks after therapy using the International Osteoporosis Foundation Qualeffo-41 score, and pain intensity was measured using a visual analogue scale. No therapy-associated complications were observed during the study. After 26 weeks, quality of life significantly increased in groups 2 and 3 compared with group 1 (p<0.001). Pain intensity decreased in group 1 by only 6 points, whereas it decreased in group 2 by 31 points and in group 3 by 24 points. Pain relief was significantly different between the ...Continue Reading

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Citations

May 7, 2015·The Cochrane Database of Systematic Reviews·Sebastian StraubeR Andrew Moore
Oct 16, 2009·Angewandte Chemie·Barbara Albert, Harald Hillebrecht
Mar 21, 2020·Der Orthopäde·L HeuchemerM Mücke
Feb 18, 2020·Der Schmerz·L HeuchemerM Mücke
Sep 5, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Karen VoigtAntje Bergmann

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