Jan 1, 1987

Influence of adrenergic agonists and antagonists on lymphokine secretion in vitro

International Journal of Immunopharmacology
I Paegelow, H Werner


Spleen cells of mice and lymph node lymphocytes of rats were cultured with epinephrine, norepinephrine and alpha- and beta-adrenergic drugs to determine effects on lymphokine secretion. After an incubation of 4.5 h it was found that the naturally occurring catecholamines and adrenergic drugs (isoprenaline, orciprenaline, terbutaline, norfenephrine, phenylephrine, clonidine, dobutamine) could induce the secretion of charge-changing lymphokines and lymphokines that stimulate the migration of lymphocytes. The beta-blocker propranolol inhibited the lymphokine secretion evoked by epinephrine and by beta-adrenergic agonists, whereas the alpha-blocker phentolamine antagonized the effects elicited by alpha-adrenergic drugs. Phenylethylamine also induced a significant secretion of lymphokines. Two non-phenylethylamines had no effect. The stimulatory capacity of adrenergic agonists, the inhibitory activity of the appropriate antagonists and the comparison with two non-phenylethylamines support the hypothesis on specific influence of catecholamines on the lymphocyte function.

Mentioned in this Paper

Mice, Inbred CBA
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
August Rats
Catecholamines Measurement
Adrenergic Agonists
Adrenergic beta-Agonists
Adrenergic alpha-Antagonists
Process of Secretion

About this Paper

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