Feb 14, 2017

Influence of age and cognitive performance on resting-state brain networks of older adults in a population-based cohort

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Christiane JockwitzKatrin Amunts


Aging leads to global changes in brain structure and cognitive performance, with reorganization of functional brain networks. Importantly, these age-related changes show higher inter-individual variability in older subjects. To particularly address this variability is a challenge for studies on lifetime trajectories from early to late adulthood. The present study therefore had a dedicated focus on late adulthood to characterize the functional connectivity in resting-state networks (RSFC) in relation to age and cognitive performance in 711 older adults (55-85 years) from the 1000BRAINS project. The executive, left and right frontoparietal resting-state (RS) networks showed age-related increases in RSFC. However, older adults did not show changes in RSFC in the default mode network (DMN). Furthermore, lower performance in working memory (WM) was associated with higher RSFC in the left frontoparietal RS network. The results suggest age-related compensatory increases in RSFC which might help to maintain cognitive performance. Nevertheless, the negative correlation between RSFC and WM performance hints at limited cognitive reserve capacity in lower performing older adults. Consequently, the current results provide evidence for a fun...Continue Reading

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Mentioned in this Paper

Memory, Short-Term
Immediate Recall
Oculodigitoesophagoduodenal Syndrome
Research Subject
Ability to Perform Cognitive Activity
Memory for Designs Test
Executive Function

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