Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort

The American Journal of Gastroenterology
Calies Menard-KatcherAmanda B Muir

Abstract

Sequelae of eosinophilic esophagitis (EoE) include food impaction and esophageal stricture. Duration of inflammation is a predicted risk factor; however, complications remain unpredictable. Studies using the functional lumen imaging probe (FLIP) have demonstrated decreased distensibility of the esophagus in adult patients with EoE. As the impact of inflammation on the developing esophagus is unknown, we investigated esophageal distensibility in a pediatric cohort to determine the effect of age, ongoing inflammation, and fibrotic features on distensibility. We conducted a prospective observational study at two tertiary pediatric institutions. Subjects underwent FLIP evaluation during endoscopy to determine distensibility of the esophagus. During stepwise distension, simultaneous intrabag pressure and 16 channels of cross-sectional areas were measured. The minimal diameter at maximal esophageal distention at an intrabag pressure of 40 mm Hg was identified. Distensibility was compared between EoE and non-EoE subjects and between clinical variables within the EoE cohort. Potential confounding variables were identified. Forty-four non-EoE and 88 EoE subjects aged 3-18 years were evaluated. Age positively correlated with esophageal d...Continue Reading

References

Sep 18, 2007·Journal of Pediatric Gastroenterology and Nutrition·Mirna ChehadeMargret S Magid
Nov 17, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Monika A KwiatekJohn E Pandolfino
Sep 23, 2010·Gastroenterology·Monika A KwiatekJohn E Pandolfino
May 20, 2015·Journal of Pediatric Gastroenterology and Nutrition·Calies Menard-KatcherLaura Z Fenton
Dec 19, 2015·Clinical and Translational Gastroenterology·Manish B SinglaFouad J Moawad
Jun 18, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D A CarlsonJ E Pandolfino
Jun 22, 2016·The American Journal of Gastroenterology·Doerthe A AndreaeMirna Chehade

❮ Previous
Next ❯

Citations

Jan 30, 2018·Journal of Leukocyte Biology·Jennifer Armbruster-LeeAmali E Samarasinghe
Sep 22, 2018·Current Opinion in Pediatrics·Melanie A Ruffner, Jonathan M Spergel
Sep 14, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eisuke InageJoanne C Masterson
Nov 6, 2018·Expert Review of Clinical Immunology·Melanie A RuffnerAntonella Cianferoni
Feb 2, 2019·Current Treatment Options in Gastroenterology·Quan M Nhu, Fouad J Moawad
Mar 2, 2018·Current Gastroenterology Reports·S M BoltonJ B Wechsler
Oct 1, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Maartje M J SingendonkUNKNOWN In Association with the European Society for Pediatric Gastroenterology, Hepatology, Nutrition (ESPGHAN) Pediatric Motility
Jan 22, 2020·Pediatric Research·Sanjay KumarSandeep K Gupta
Feb 11, 2020·Current Gastroenterology Reports·Erica N Donnan, John E Pandolfino
Nov 30, 2019·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Swathi EluriEvan S Dellon
Aug 20, 2020·Annals of the New York Academy of Sciences·John O ClarkeMarcelo F Vela
Aug 10, 2020·The American Journal of Gastroenterology·C Prakash GyawaliRena H Yadlapati
Nov 21, 2018·Frontiers in Immunology·Benjamin F SallisEdda Fiebiger
Jul 17, 2020·Digestive Diseases and Sciences·Y Claire DorseyAmit Patel
Jan 23, 2018·Current Treatment Options in Gastroenterology·Ronak Vashi Patel, Ikuo Hirano
Apr 28, 2018·The American Journal of Gastroenterology·Marijn J WarnersAlbert J Bredenoord
Nov 13, 2018·Journal of Pediatric Gastroenterology and Nutrition·Maheen HassanHayat Mousa
Sep 23, 2020·Journal of Pediatric Gastroenterology and Nutrition·Nathalie NguyenCalies Menard-Katcher
May 22, 2018·Frontiers in Pediatrics·Kunsong LeeNathalie Nguyen
Aug 14, 2018·Journal of Gastroenterology·Amanda B MuirHiroshi Nakagawa
Jan 3, 2020·Abdominal Radiology·Patricia V HernandezJennifer L Horsley-Silva
Aug 3, 2020·The American Journal of Gastroenterology·Edoardo SavarinoC Prakash Gyawali
Jan 9, 2020·The Journal of Allergy and Clinical Immunology·Nirmala P Gonsalves, Seema S Aceves
Feb 9, 2021·The Journal of Allergy and Clinical Immunology·Lance Y HsiehSeema S Aceves
Jul 29, 2020·Gastroenterology Clinics of North America·Erica N Donnan, John E Pandolfino
Apr 20, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Alain J BenitezPetar Mamula
Jul 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Girish HiremathEvan S Dellon
Oct 6, 2021·JAMA : the Journal of the American Medical Association·Amanda Muir, Gary W Falk
Oct 17, 2021·Journal of Gastroenterology and Hepatology·Natalie BhesaniaSophia Patel
Oct 3, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Prerana WilliamsonSeema Aceves
Dec 6, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Claire A BeveridgeKristle L Lynch
Dec 22, 2021·The American Journal of Gastroenterology·Girish HiremathEvan S Dellon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

© 2022 Meta ULC. All rights reserved