Influence of age and gender on cytokine expression in a murine model of Parkinson's disease

Neuroimmunomodulation
A CiesielskaA Członkowski

Abstract

The neuroinflammatory reaction has been linked with Parkinson's disease. One of the hypotheses to explain the significance of age and gender (male predominance) effects on neurodegeneration in Parkinson's disease may result from a link between these risk factors and the inflammatory processes. Here, we investigated the expression of inflammatory mediators in relation to 1-methyl-4-phenyl-1,2,3,6-tetrahydropiridine (MPTP)-induced neurodegenerative processes in nigrostriatal pathway in young and aged male and female mice. We simultaneously assessed striatal tyrosine hydroxylase (TH) protein concentrations (Western blotting) and cytokine (TNFalpha, IFNgamma, IL-1beta, IL-6 and TGFbeta(1)) mRNA levels (RT-PCR) in young and aged (2- and 12-month-old) C57BL/6 male and female mice after 6 h, 1, 3, 7, 14, 21 days after MPTP intoxication. Western blotting analysis showed that at the early time points, males showed a greater reduction in striatal TH versus females. Additionally, in contrast to the aged mice, in young males and females the TH concentration gradually increased between the 7th and the 21st day after intoxication. The increases in TNFalpha, IL-1beta and IFNgamma after intoxication were faster in both young and aged males tha...Continue Reading

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Citations

Sep 25, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Agnieszka CiesielskaA Członkowski
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Onder AlbayramAndras Bilkei-Gorzo
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Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Roberto Cosimo Melcangi, Luis M Garcia-Segura
Oct 11, 2017·Alzheimer Disease and Associated Disorders·Eleanor King, Alan Thomas
Sep 17, 2019·Journal of Parkinson's Disease·Holly F GreenPer Svenningsson
Jul 10, 2021·Frontiers in Neurology·Albert Frank MagnusenManoj Kumar Pandey

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