PMID: 15374459Jan 1, 1991Paper

Influence of age and gender on the levels of histamine metabolites and pros-methylimidazoleacetic acid in human cerebrospinal fluid

Archives of Gerontology and Geriatrics
G D PrellJ P Green

Abstract

The metabolites of histamine, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), were measured in cerebrospinal fluid (CSF) from 47 subjects with neurological disorders and healthy controls. In lumbar CSF, concentrations of these metabolites were significantly correlated. Levels of t-MH, t-MIAA and their sum (which represents virtually all histamine metabolized in brain) were significantly higher in CSF from older subjects and were positively correlated with age. Females had higher levels of histamine metabolites than males. Males had higher levels of pros-methylimidazoleacetic acid (p-MIAA), an isomer of t-MIAA that is not a metabolite of histamine. Levels of p-MIAA increased with age among men. Analysis of covariance indicated that the subjects' health status had little or no effect on age- or sex-related differences in levels of analytes in CSF; sex-related differences were independent of changes attributed to age. These results are in contrast to those of age-related effects on levels of other aminergic transmitter metabolites in CSF and suggest that metabolic activity of histamine in brain may increase with age.

References

Jun 23, 1986·Life Sciences·I M Mazurkiewicz-Kwilecki, G D Prell
Jan 1, 1989·Canadian Journal of Physiology and Pharmacology·I M Mazurkiewicz-Kwilecki, S Nsonwah
Jan 1, 1986·Annual Review of Neuroscience·G D Prell, J P Green
Oct 1, 1987·Agents and Actions·J P GreenP Blandina
Apr 1, 1988·Agents and Actions·E OostingR J Scholtis
Jan 15, 1986·Biochemical Pharmacology·L B HoughJ P Green
Jul 8, 1985·Brain Research·T N Ferraro, T A Hare
Jan 1, 1974·European Neurology·L R GjessingJ Presthus
Mar 30, 1973·Brain Research·J F LipinskiR J Baldessarini
May 1, 1970·Comparative Biochemistry and Physiology·K G Crush
Nov 1, 1971·European Journal of Pharmacology·J C SchwartzM Verdiere-Sahuque
May 19, 1980·Life Sciences·S N Pradhan
Jun 1, 1980·Archives of General Psychiatry·J F LeckmanM B Bowers
Jul 1, 1980·Annals of Neurology·W E SeifertI J Butler
Aug 1, 1983·Neuroscience·F Roberts, C R Calcutt
Jun 1, 1983·Computer Programs in Biomedicine·M A Moussa
Jan 16, 1984·Brain Research·L B HoughJ P Green
Apr 1, 1984·Agents and Actions·I M Mazurkiewicz-Kwilecki, G D Prell
Dec 15, 1982·Biochemical Pharmacology·L B HoughJ P Green
Mar 1, 1981·Journal of Pharmacological Methods·L B HoughJ P Green
Feb 24, 2001·Journal of Health Politics, Policy and Law·J White
Apr 28, 1954·The Journal of Physiology·D C HARDWICK
Jan 1, 1983·Neurochemistry International·J A Hardy, P R Dodd

❮ Previous
Next ❯

Citations

Jan 1, 1995·Annals of Neurology·J J RoznieckiT C Theoharides
Nov 7, 2007·Neuromolecular Medicine·José A G AgúndezElena García-Martín
Oct 20, 2001·Behavioural Brain Research·L BacciottiniP Blandina
Mar 3, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Robert A Weale
Jan 13, 2015·Trends in Neurosciences·Ling ShanDick F Swaab
May 29, 2008·Biomedical Chromatography : BMC·Toshimasa Toyo'oka
Nov 26, 2010·Brain Pathology·Daniel J van WamelenDick F Swaab
Jul 31, 2014·Journal of Neuroendocrinology·D J van WamelenD F Swaab
Sep 26, 2008·Biological Psychiatry·Masahiko YoshizawaMichio Hongo
Nov 27, 2014·Frontiers in Cellular Neuroscience·Félix J Jiménez-JiménezJosé A G Agúndez
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Natasha L Lethbridge, Paul L Chazot
Nov 13, 2003·Health Promotion Practice·David Haber, Carol Looney
Jul 21, 2021·ACS Chemical Neuroscience·Siwei ChenAmal Alachkar

❮ Previous
Next ❯

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.