PMID: 15374496Jul 1, 1990Paper

Influence of age and gender on the levels of histamine metabolites and pros-methylimidazoleacetic acid in human cerebrospinal fluid

Archives of Gerontology and Geriatrics
G D PrellJ P Green

Abstract

The metabolites of histamine, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), were measured in cerebrospinal fluid (CSF) from 47 subjects with neurological disorders and healthy controls. In lumbar CSF, concentrations of these metabolites were significantly correlated. Levels of t-MH, t-MIAA and their sum (which represents virtually all histamine metabolized in brain) were significantly higher in CSF from older subjects and were positively correlated with age. Females had higher levels of histamine metabolites than males. Males had higher levels of pros-methylimidazoleacetic acid (p-MIAA), an isomer of t-MIAA that is not a metabolite of histamine. Levels of p-MIAA increased with age among men. These results are in contrast to those of age-related effects on levels of other aminergic transmitter metabolites in CSF and suggest that metabolic activity of histamine in brain may increase with age.

References

Jun 23, 1986·Life Sciences·I M Mazurkiewicz-Kwilecki, G D Prell
Jan 1, 1989·Canadian Journal of Physiology and Pharmacology·I M Mazurkiewicz-Kwilecki, S Nsonwah
Jan 1, 1986·Annual Review of Neuroscience·G D Prell, J P Green
Oct 1, 1987·Agents and Actions·J P GreenP Blandina
Apr 1, 1988·Agents and Actions·E OostingR J Scholtis
Jan 15, 1986·Biochemical Pharmacology·L B HoughJ P Green
Jul 8, 1985·Brain Research·T N Ferraro, T A Hare
Jan 1, 1974·European Neurology·L R GjessingJ Presthus
Mar 30, 1973·Brain Research·J F LipinskiR J Baldessarini
May 1, 1970·Comparative Biochemistry and Physiology·K G Crush
Nov 1, 1971·European Journal of Pharmacology·J C SchwartzM Verdiere-Sahuque
May 19, 1980·Life Sciences·S N Pradhan
Jun 1, 1980·Archives of General Psychiatry·J F LeckmanM B Bowers
Jul 1, 1980·Annals of Neurology·W E SeifertI J Butler
Aug 1, 1983·Neuroscience·F Roberts, C R Calcutt
Jan 16, 1984·Brain Research·L B HoughJ P Green
Apr 1, 1984·Agents and Actions·I M Mazurkiewicz-Kwilecki, G D Prell
Dec 15, 1982·Biochemical Pharmacology·L B HoughJ P Green
Mar 1, 1981·Journal of Pharmacological Methods·L B HoughJ P Green
Apr 28, 1954·The Journal of Physiology·D C HARDWICK
Jan 1, 1983·Neurochemistry International·J A Hardy, P R Dodd

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Citations

Jan 31, 2012·Neurobiology of Aging·Ling ShanDick F Swaab

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