Influence of Age and Neurotoxic HAART Use on Frequency of HIV Sensory Neuropathy.

AIDS Research and Treatment
Olajumoke OshinaikeMustapha Danesi

Abstract

Background. Sensory neuropathy (SN) is one of the most common AIDS-associated neurologic disorders especially in the era of highly active antiretroviral therapy (HAART). The aim of this study was to determine the prevalence of SN among highly-active-antiretroviral-therapy- (HAART-) experienced and HAART-naïve HIV-positive individuals and to investigate the relationship to demographic, clinical, and laboratory factors. Methods. 323 patients with HIV infection (142 on HAART and 181 HAART naïve) were enrolled in a cross-sectional neuropathy screening program. Data was collected using structured questionnaires which contained the brief peripheral neuropathy screening tool of AIDS Clinical Trial Group protocol. Neuropathy was defined by the presence of at least 1 clinical sign in a distal, symmetrical pattern. Patients were classified as symptomatic if they described aching, stabbing, or burning pain, paresthesia, or numbness in a similar distribution. Demographic, clinical, and laboratory details were documented as risk factors. Result. The prevalence of sensory neuropathy was 39.0% (126/323), (of which 29/126 (23%)) were symptomatic. Amongst those on HAART, 60/142 (42.3%) had SN compared to 66/181 (36.5%) HAART-naïve individuals (...Continue Reading

References

Jun 27, 2002·Neurology·G SchifittoUNKNOWN Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders
Feb 26, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Catherine L CherrySteven L Wesselingh
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth A LichtensteinUNKNOWN HIV Outpatient Study Investigators
Mar 9, 2005·Neurology·G SchifittoUNKNOWN NEAD Consortium

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Citations

Aug 2, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cindy TofthagenYating Yeh
Jul 19, 2018·PLoS Neglected Tropical Diseases·Marilia Brasil XavierCarlos Eduardo Pereira Corbett
Oct 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alyssa C VecchioKevin Robertson
Nov 25, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Karen Cilliers, Christo J F Muller

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS

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