Influence of age at infection on human immunodeficiency virus disease progression to different clinical endpoints: the SEROCO cohort (1988-1994). The Seroco Study Group

International Journal of Epidemiology
F BelangerC Deveau

Abstract

The influence of age at infection on progression of human immunodeficiency virus (HIV) disease to different clinical endpoints was studied among 393 HIV-seropositive adults selected from the French SEROCO cohort; follow-up lasted from January 1988 to November 1994. Selected patients had a known date of infection and were enrolled shortly after seroconversion. Age-associated risk ratios (RR) were estimated using the Cox model (age fitted as a continuous variable and RR expressed for each 10-year increment after adjustment for symptomatic primary infection and sexual preference). Age had a weak influence on progression from the date of infection to the first category B event (crude RR = 1.15; adjusted RR = 1.09; 95% confidence interval [CI]: 0.89-1.36) but a marked influence on progression from the first category B to the first category C event (crude RR = 1.95; adjusted RR = 1.97; 95% CI: 1.37-2.79). Similar results were obtained after adjustment for the CD4+ cell count at enrollment. A qualitative CD4+ cell defect could explain the influence of age, but this remains to be confirmed. Age at infection should be included in the definition of CD4+ cell count thresholds for clinical management and treatment initiation. Risk factors ...Continue Reading

Citations

Jan 11, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John L Perez, Richard D Moore
Sep 11, 2010·AIDS·Keri N AlthoffUNKNOWN North American AIDS Cohorts Collaboration on Research, Design (NA-ACCORD)
Feb 2, 2008·International Review of Psychiatry·Raul Gonzalez, Mariana Cherner
Oct 22, 2011·Enfermedades infecciosas y microbiología clínica·Susana MongeUNKNOWN Grupo de Seroconvertores de la Comunidad de Madrid
May 16, 2009·Revista española de geriatría y gerontología·Fátima Brañas, José Antonio Serra
Jul 17, 2007·Clinics in Geriatric Medicine·Vera P Luther, Aimee M Wilkin
Apr 26, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Amara E EzeamamaChristopher C Whalen
Oct 11, 2012·Biometrical Journal. Biometrische Zeitschrift·Juliette PénichouxAurélien Latouche
May 17, 2013·Journal of the International Association of Providers of AIDS Care·Camila Lourencini CavellaniLaura Penna Rocha
Apr 13, 2004·AIDS·Marianna ChernerUNKNOWN HIV Neurobehavioral Research Center Group
Dec 22, 2007·AIDS·Wayne M Getz
Oct 17, 2002·Drugs & Aging·Roberto Manfredi
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter I LoboJennifer A White
Oct 3, 2018·Japanese Journal of Infectious Diseases·Hiroshi Yoshikura

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