PMID: 9435037Jan 1, 1997Paper

Influence of age, gender and smoking on Streptococcus pneumoniae, Haemophilus influenzae and Moraxella (Branhamella) catarrhalis antibody titres in an elderly population

Scandinavian Journal of Infectious Diseases
P KurttiM Leinonen

Abstract

The purpose of this study was to investigate the association of serum antibody levels to Streptococcus pneumoniae, Haemophilus influenzae and Moraxella (Branhamella) catarrhalis with age, gender and smoking in an elderly population. The study population comprised all the inhabitants aged 65 years or over in a rural municipality in south-western Finland. Serum samples were obtained from 1,174 out of a total of 1,360 subjects. Bacterial antibodies were measured by enzyme immunoassay (EIA) using pneumolysin and whole bacterial cells of H. influenzae and M. catarrhalis (mixture of 10 different strains for both) as antigens. The main findings were as follows: (i) antibody levels generally decreased with increasing age both in men and in women; (ii) antibody titres against H. influenzae and M. catarrhalis were higher in men than in women; and (iii) antibody titres to H. influenzae and M. catarrhalis, but not to S. pneumoniae, were significantly higher in smokers than in non-smokers. These data suggest that antibody-mediated protection against respiratory pathogens may be impaired in the elderly, leading to a higher susceptibility to respiratory tract infections, that the exposure to H. influenzae and M. catarrhalis may be higher in m...Continue Reading

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Aug 16, 2008·International Journal of Cancer. Journal International Du Cancer·Annamari KilkkinenPaul Knekt
Jul 27, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·E CiftçiU D Aysev
Apr 21, 2017·Clinical and Vaccine Immunology : CVI·Hugh AdlerJamie Rylance
Oct 5, 2018·The Laryngoscope·Ashton E LehmannRalph Metson
Jun 30, 2005·Breast Cancer Research and Treatment·Rebecca C DidhamKen S Harrison
Mar 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dana N MitzelHeather W Stout-Delgado
May 12, 2020·The Annals of Otology, Rhinology, and Laryngology·Thomas HolmesStilianos E Kountakis
Oct 23, 2020·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Anubhuti DhanukaDebasis Jena

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