Influence of Age on Global and Regional Brain Stiffness in Young and Middle-Aged Adults.

Journal of Magnetic Resonance Imaging : JMRI
Tomohiro TakamuraHiroshi Onishi

Abstract

An understanding of potential age-related changes in brain stiffness and its regional variation is important for further clinical application of MR elastography. To investigate the effect of age on global and regional brain stiffness in young and middle-aged adults. Prospective. Fifty subjects with normal brains and aged in their 20s, 30s, 40s, 50s, or 60s (five men, five women per decade). 3.0T MRI and elastography with a vibration frequency of 60 Hz. Stiffness was measured in nine brain regions (cerebrum, temporal lobes, sensorimotor areas, frontotemporal composite region, deep gray matter and white matter (deep GM/WM), parietal lobes, occipital lobes, frontal lobes, and cerebellum) using an atlas-based region-of-interest approach. The influence of age on regional brain stiffness was evaluated. Multiple linear regression analysis, followed by Dunnett's multiple comparisons test, using subjects in their 20s as controls. Following adjustment for sex, multiple linear regression revealed a significant negative correlation between age and stiffness of the cerebrum (P < 0.0001), temporal lobes (P < 0.0001), sensorimotor areas (P < 0.0001), frontotemporal composite region (P < 0.0001), deep GM/WM (P = 0.0028), parietal lobes (P < 0....Continue Reading

References

Jan 1, 1991·Biological Psychiatry·T L JerniganJ R Hesselink
Jun 1, 1987·Annals of Neurology·R D TerryL A Hansen
May 5, 1998·Neurology·C R GuttmannM S Albert
Jun 28, 2000·Physics in Medicine and Biology·S A KruseR L Ehman
Jul 11, 2001·Neurobiology of Aging·T L JerniganJ R Hesselink
Dec 4, 2001·Medical Image Analysis·A ManducaR L Ehman
Jan 30, 2004·Neurobiology of Aging·Edith V SullivanAdolf Pfefferbaum
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Apr 27, 2005·Human Brain Mapping·Stuart M GrieveEvian Gordon
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Oct 6, 2007·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·M ScholzK Schmieder
Nov 28, 2007·Annual Review of Pathology·Bruce A YanknerPatrick Loerch
Mar 14, 2009·NeuroImage·Ingolf SackJürgen Braun
Mar 3, 2010·Neurosurgical Review·Antonio Di IevaRiccardo Rodriguez Y Baena
Oct 27, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yun-Bi LuJosef A Käs
Jun 15, 2011·Physics in Medicine and Biology·Huifang WangKeith D Paulsen
Jul 14, 2011·Journal of Magnetic Resonance Imaging : JMRI·Matthew C MurphyRichard L Ehman
Jul 2, 2015·Journal of Magnetic Resonance Imaging : JMRI·John HustonRichard L Ehman
Oct 6, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Richa Hanamsagar, Staci D Bilbo
Nov 7, 2015·AJNR. American Journal of Neuroradiology·N FattahiJ Huston
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Simon ChatelinZsolt Lenkei
Feb 24, 2016·NeuroImage. Clinical·Matthew C MurphyJohn Huston
Jun 2, 2017·AJR. American Journal of Roentgenology·Mona ElSheikhJohn Huston

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Citations

Sep 3, 2020·Surgical Neurology International·Giuseppe Emmanuele UmanaGianluca Scalia
Aug 28, 2020·Frontiers in Aging Neuroscience·Alexandra M NicaiseStefano Pluchino
Jan 14, 2021·Biomedical Physics & Engineering Express·G Costa, F Gentile
Feb 23, 2021·NeuroImage·Lucy V HiscoxCurtis L Johnson
May 1, 2021·Micromachines·Tiffany CameronKaren C Cheung
May 6, 2021·APL Bioengineering·Nicolas Marinval, Sing Yian Chew
May 25, 2021·Brain Research Bulletin·Aleeza Zilberman, R Chase Cornelison

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