Influence of age on oxidative bursts (chemiluminescence) of polymorphonuclear neutrophil leukocytes

Gerontology
P C BragaG Annoni

Abstract

The release of reactive oxygen species (ROS) during neutrophil oxidative bursts is the last of a sequence of different steps leading to the neutralization of pathogen microorganisms. Using luminol-amplified chemiluminescence (LACL), the oxidative burst activity of neutrophils in elderly people (> or = 75 years) was compared with that in younger controls (39 years on average) after activation with both particulate (Candida albicans) and soluble (formyl-methionyl-leucyl-phenylalanine; fMLP) stimulants. After Candida stimulation, a reduction in LACL was observed in the elderly subjects in comparison with the controls, but the difference did not reach statistical significance. After fMLP stimulation, the reduction in LACL was significant, thus suggesting that the Candida pathway of chemiluminescence production seems to be less affected than the fMLP pathway. This finding raises questions concerning the complex differences in the pathways of cell killing and ROS generation, and their efficacy in the elderly. Various possible explanations are discussed, all of which need further investigation.

Citations

Aug 21, 2001·Mechanisms of Ageing and Development·J M LordM Salmon
Apr 26, 2003·Mechanisms of Ageing and Development·Anja Kristina Schröder, Lothar Rink
Oct 8, 1998·Experimental Gerontology·P C BragaC Vergani
Jan 17, 2002·Immunopharmacology and Immunotoxicology·C TortorellaS Antonaci
Mar 31, 2009·Immunity & Ageing : I & a·Thaís Helena GasparotoVanessa Soares Lara
Dec 18, 2013·Aging Clinical and Experimental Research·Rohit SharmaSuman Kapila
Apr 3, 2003·Annals of Plastic Surgery·Arian MowlaviRobert C Russell
Dec 17, 2008·Free Radical Biology & Medicine·Emilie VenturaJean-Paul Cristol
Mar 24, 2009·Luminescence : the Journal of Biological and Chemical Luminescence·Margarita L Alexandrova
Feb 7, 2006·Seminars in Oncology Nursing·Margaret H Crighton, Alicia A Puppione
Jul 22, 2014·Journal of Gastroenterology and Hepatology·Irma Garcia-MartinezJosé Such
Jul 11, 2014·Biogerontology·Jon Hazeldine, Janet M Lord
Apr 10, 2017·Ageing Research Reviews·Connie JackamanDelia J Nelson

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