PMID: 518178Dec 1, 1979Paper

Influence of age on the endocrine-metabolic response to surgery

Annals of Surgery
M Blichert-ToftK Olgaard

Abstract

The pathogenesis of the increased operative risk in elderly patients is unknown. From a theoretical point of view, a change in endocrine-metabolic response might be involved. In the present study, a battery of hormonal and metabolic variables were measured in eight young and eight elderly healthy males undergoing elective inguinal hernial repair under general anesthesia. Blood was drawn before induction of anesthesia, at skin incision, and one, two, and six hours after skin incision. The findings were: 1) Plasma cortisol increase was significantly higher in elderly than in young controls. 2) Plasma renin level was lower in old age, but renin-aldosterone and electrolyte response patterns were alike in the two groups. 3) Thyroid parameters, in terms of serum T4, serum T3, serum rT3, and T3-resin uptake, responded normally to surgery and showed no age-related differences. 4) The hyperglycemic response was not significantly influenced by age indicating unchanged glycoregulatory mechanisms also verified by determinations of plasma catecholamines, cAMP, and insulin. 5) Blood lymphocyte count was constantly lower in elderly than in young and decreased with time, but the age-related difference was not significant. 6) Blood polymorphonu...Continue Reading

References

Sep 1, 1976·Journal of Gerontology·M Blicher-Toft, L Hummer
Mar 1, 1978·The British Journal of Surgery·S N MadsenA Engquist
Jun 1, 1979·Acta Anaesthesiologica Scandinavica·M R BrandtH Kehlet
Dec 1, 1977·The British Journal of Surgery·H KehletP Platz
Oct 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·B E Karlberg, K Tolagen
Apr 1, 1978·The British Journal of Surgery·A EngquistH Kehlet
Oct 1, 1977·Archives of Internal Medicine·R H NothP J Mulrow
Jan 1, 1975·The Journal of Clinical Investigation·A S Fauci, D C Dale
Jul 1, 1970·Acta Endocrinologica·B Blichert-Toft, M Blichert-Toft
Jan 1, 1974·Acta Endocrinologica·H KehletC Engbaek
Oct 1, 1960·Annals of Surgery·P W HERRONH N HARKINS
Oct 1, 1961·The Journal of Clinical Endocrinology and Metabolism·C D WESTE ENGLERT

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Citations

Nov 14, 1997·The Journal of Trauma·C SartorettiP Buchmann
Jan 1, 1985·Acta Anaesthesiologica Scandinavica. Supplementum·A Engquist
May 31, 1994·Annals of the New York Academy of Sciences·M A Horan

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