PMID: 7537592Feb 1, 1995Paper

Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus

British Journal of Pharmacology
G J Smits, R A Lefebvre

Abstract

1. The influence of aging on the relaxant response and the change in cyclic nucleotide content induced by vasoactive intestinal polypeptide (VIP), nitric oxide (NO), electrical field stimulation of the non-adrenergic non-cholinergic neurones and substances acting at different levels of the cyclic AMP and cyclic GMP transduction pathways was studied in longitudinal muscle strips of the rat gastric fundus. 2. The relaxant responses to VIP, sustained electrical stimulation, forskolin and 3-isobutyl-1-methylxanthine were reduced with age, while the responses to dibutyryl cyclic AMP were not. The increase in cyclic AMP content induced by sustained electrical stimulation and forskolin was lower in old rats. 3. The relaxant responses to NO and to short train electrical stimulation were similar in the three age groups. The inhibitory effect of NG-nitro-L-arginine methyl ester on relaxations induced by short train electrical stimulation was more pronounced in old rats. The relaxant responses to sodium nitroprusside (SNP), 8-bromo-cyclic GMP and zaprinast were reduced with age. SNP induced a similar elevation of the cyclic GMP content in the three age groups. 4. These results suggest that aging differentially affects the cyclic AMP and c...Continue Reading

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Citations

May 6, 1996·European Journal of Pharmacology·G J Smits, R A Lefebvre
Mar 23, 2002·European Journal of Pharmacology·Alessandro SerrettiEnrico Smeraldi
Mar 4, 1999·European Journal of Pharmacology·T IchikawaK Hotta
Feb 17, 2000·Trends in Neurosciences·P CalabresiG Bernardi
Mar 23, 2000·Progress in Neurobiology·P CalabresiG Bernardi
Mar 1, 1997·Journal of Pharmacological and Toxicological Methods·G J Smits, R A Lefebvre
Mar 1, 1997·British Journal of Pharmacology·R A Lefebvre, L Barthó
Oct 1, 1995·British Journal of Pharmacology·R A LefebvreJ P Timmermans
Oct 25, 2011·Climacteric : the Journal of the International Menopause Society·L A S LaraA C J S Rosa-e-Silva
Feb 19, 2005·Neurobiology of Aging·Cristoforo ScavoneRegina Pekelmann Markus
Aug 2, 2015·Age·Adam WysokińskiTomasz Kostka
Oct 29, 2009·The American Journal of Gastroenterology·Hye-Kyung JungNicholas J Talley
Jun 12, 2001·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·F HataA Fujita
Oct 9, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·John E Morley
Aug 20, 2005·Pharmacological Reviews·Noboru Toda, Arnold G Herman

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