PMID: 11329489May 1, 2001Paper

Influence of age, sex, and Helicobacter pylori infection before and after eradication on gastric alcohol dehydrogenase activity

Alcoholism, Clinical and Experimental Research
S KechagiasA W Jones

Abstract

Gastric alcohol dehydrogenase may contribute to the metabolism of orally ingested ethanol and decrease the bioavailability of the drug. The aims of this study were to assess the impact of Helicobacter pylori infection and its eradication on gastric alcohol dehydrogenase activity and to relate the findings to gastric histology. Furthermore, the role of age- and sex-related differences in gastric alcohol dehydrogenase activity were studied. A total of 76 subjects (39 women and 37 men) underwent upper gastrointestinal endoscopy, and biopsies were obtained from the corpus and antrum. The specimens were used for determining gastric alcohol dehydrogenase activity, histological examination, and urease testing. Subjects with H. pylori infection (n = 36) received medication to eradicate the infection, and repeat biopsies were taken 2 and 12 months later. No significant difference in gastric alcohol dehydrogenase activity was found between men and women (p > 0.05). Gastric alcohol dehydrogenase activity did not differ significantly between the subjects older than 50 years (n = 39) and those 50 years or younger (n = 37). In subjects with H. pylori infection, gastric alcohol dehydrogenase activity was significantly reduced in the antrum (p...Continue Reading

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Citations

Jun 28, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manuela GrazianiRobert Nisticò
Apr 4, 2007·Digestive Diseases and Sciences·Wojciech JelskiMaciej Szmitkowski
Apr 30, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michinaga MatsumotoToshifumi Hibi

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