PMID: 3746926Aug 1, 1986Paper

Influence of agents that alter lysosomal function on fetal mouse hearts recovering from anoxia and substrate depletion

Journal of Molecular and Cellular Cardiology
R M RidoutR S Decker

Abstract

Recovery of fetal mouse heart myocytes from oxygen and substrate deprivation for 1 h is accompanied by complicated lysosomal and non-lysosomal vacuolar responses which can be subdivided temporally into four distinct phases that include production of lysosomal dense bodies; segregation of damaged subcellular organelles into vacuoles that initially lack lysosomal enzymes; delivery of lysosomal enzymes to these vacuoles through fusion with dense bodies, transforming them into lysosomal autophagic vacuoles and degradation of the sequestered organelles. These events are normally completed within 6 h of the resupply of oxygen and substrate. The progression of these events is influenced significantly by pharmacological interventions that alter lysosomal properties. Chloroquine inhibits all aspects of the lysosomally-related processes as well as the sequestration phase during recovery. Leupeptin delays the lysosomal degradation, presumably by slowing proteolysis. Hydrocortisone permits the engulfment phase and the appearance of lysosomal dense bodies but appears to prevent or postpone the delivery of lysosomal enzymes to many of the large vacuoles and to delay the degradation of sequestered organelles. These observations reveal that se...Continue Reading

Citations

Dec 1, 1988·Cardiovascular Drugs and Therapy·L H Opie, W A Coetzee
Apr 1, 2017·Nature Reviews. Cardiology·Lea M D DelbridgeRoberta A Gottlieb
Dec 31, 1992·Annals of the New York Academy of Sciences·R A NixonL Kanaley-Andrews

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